Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Hereditas(Beijing)》 2002-01
Add to Favorite Get Latest Update

Germ Cells in the Murine Embryonic Development

HAN Rong,SHANG Ke-gang (College of Life Sciences,Peking University,Beijing 100871,China)  
This paper reviewed the recent progress of the origin,migration and proliferation,sex determination,and genomic modification of murine germ cells during its embryonic development. Murine germ cells originate from primordial germ cells at about 7~7.5dpc. Then PGCs migrated into germinal ridge at about 12.5dpc during which Steel/c-kit signal pathway plays important roles and stopped division at 13.5dpc. The sex of germ cells was mainly determined by the soma microenvironment in the gonad. And there are essential genes for sperm formation on the Y chromosome. The de novo methylation of murine germ cells was much later than soma cells and was completed at about 18.5dpc. The X chromosome reactivation of female germ cells was finished at about 14.5~15.5dpc which was independent of sexual differentiation of germinal ridge.
【Fund】: 国家自然科学基金资助课题 ( 39730 2 5 0 )
【CateGory Index】: Q954.53
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved