Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Hereditas(Beijing)》 2005-03
Add to Favorite Get Latest Update

Progress of Research on Epigenetic and Human Disease

ZHANG Yong-Biao, CHU Jia-You(Department of Genetics, Institute of Medical Biology, Peking Union Medical College, Kunming 650118, China)  
In the past few fears, there has been a nascent convergence of scientific understanding of human disease with epigenetic. Identified epigenetic processes involved in human disease include chromatin remodeling, genomic imprinting, X chromosome inactivation, and noncoding RNAs regulation. These processes influence chromatin structure and thereby regulate gene expression on the chromosome level or a cluster of linked genes level. Deregulation of these processes result in lots of disease which are characterized by complex patterns of mutations and associated phenotypes affecting pre- and postnatal growth, development, and neurological function. Epigenetic diseases are illustrated by the array of multi-system disorders and neoplasias and investigations of these diseases have an impact on biomedical research and provide interesting models for functions and mechanisms of epigenetic gene control.
【Fund】: 国家自然科学基金(39993420)和国家科技部“十五”攻关项目(2002BA711A08)资助~~
【CateGory Index】: R394
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 ZHANG Li-Xia1, PAN Shi-Yang1, CHEN Dan1, XIE Er-Fu1, GAO Li1, SHU Yong-Qian2, LU Zu-Hong3, CHENG Lu3, YANG Di4, ZHANG Ji-Nan4 1. Center of Clinical Laboratory, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China 2. Department of Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China 3. Department of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, P. R. China 4. Department of Cardiovascular Disease, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China;Effect of Adenomatous Polyposis Coli(APC) Promoter Methylation on Gene Transcription in Lung Cancer Cell Lines[J];Chinese Journal of Cancer;2007-06
2 TENG Li-Juan, LI KeDepartment of Molecular Epidemiology, Medical College, Shantou University, Shantou, Guangdong, 515041, P. R. China;Research Progress on the Relationship between Nutrition and Cancer Epigenetics——Histone Modification Mechanisms[J];Chinese Journal of Cancer;2007-09
3 Hong-Li Li,1 Wei-Dong Zhang,2 Wen-Tong Li2 and Chong-Gao Yin31.Medicine Research Experiment Center of Science Research, Weifang Medical College, Weifang, Shandong, 261042, P.R.China 2.Department of Pathology, Weifang Medical College, Weifang, Shandong, 261042, P.R.China 3.Department of Nursing, Weifang Medical College, Weifang, Shandong, 261042, P.R.China;Effect of 5-Aza-dC on FHIT gene expression in hepatocellular carcinoma cell line HepG2[J];Chinese Journal of Cancer;2009-09
4 YANG Hong-dan,GAO Shi-yong(Cneter of Research and Development on Life Scineces and Environmental Sciences,Harbin University of Comerce,Harbin 150076,China);Relationship between DNA methylation aberration and human tumor[J];Journal of Harbin University of Commerce(Natural Sciences Edition);2007-04
5 WANG Zheng-chao,PAN Xiao-yan,PANG Xun-sheng (1.College of Animal Science and Technology,Nanjing Agricultural University, Nanjing 210095,China; 2.Anhui College of Science and Technology,Bengbu 233100,China);Dosage Compensation of Early Embryo and Its Effect on the Development of Mammals[J];Acta Ecologiae Animalis Domastici;2006-06
6 ZHAO Ying~1,ZHOU Yu-xun~2,LI Kai~2,XIAO Jun-hua~2(1.School of Bioengineering,East China University of Science and Technology,Shanghai 200237,China;2.Institute of Biology Science and Technology,Donghua University,Shanghai 201620,China);Relationship between LHβ,FSHβ Genes and Central Precocious Puberty in Chinese Girls Based on the Polymorphisms in the 5′-Flanking Regions[J];Journal of East China University of Science and Technology(Natural Science Edition);2009-04
7 GU Ting-ting~(1,2),ZHANG Zhong-ming~1,ZHENG Peng-sheng~(1,2)(1.Department of Gynecology and Obstetrics,The First Affiliated Hospital of Medical College,Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;2.Key Laboratory of Environment and Genes Related to Diseases,Medical College,Xi'an Jiaotong University,Ministry of Education,Shaanxi Xi'an 710061,China);Review and evaluation of methodology of research on DNA methylation[J];Chinese Journal of Maternal and Child Health Research;2006-06
8 WANG Xia,QIN Xiuli(Jilin Agricultural Science and Technology College Department of Bioengineering,Jilin 132101,China);On the Producing,Mechanism and Biology Meaning of Epigenetics[J];Journal of Jilin Agricultural Science and Technology College;2008-04
9 ZOU Wei-shu~1 YANG Sheng-lin~2 (1 The Vocational High School of Panxian County of Guizhou,Panxian Guizhou 553536 China) (2 College of Animal Science,Guizhou University,Guiyang Guizhou 550025 China);DNA Numerical System and Information Transfer in the Catalytical Process of Enzyme[J];Journal of Biomathematics;2010-01
10 DENG Hong-Xia1),GUO Jun-Ming1),XIAO Bing-Xiu1),CUI Long1),Caigan DU2)(1) Institute of Biochemistry and Molecular Biology,School of Medicine,Ningbo University,Ningbo 315211,Zhejiang,China;2) Jack Bell Research Centre,University of British Columbia,Vancouver,BC V6 H 3 Z6,Canada);Epigenetic Regulation of microRNA Gene Expression in Gastric Carcinoma[J];Chinese Journal of Biochemistry and Molecular Biology;2010-12
Chinese Journal Full-text Database 10 Hits
1 Yuan Zhenhua, Ding Youchang, Chen Xiaojun, Wang Mingfa, Yang Zhangping Hangzhou Sanitation and Anti epidemic Station, Hangzhou\ 310006;STUDY ON THE SAFETY OF INDOOR ORNAMENTAL MATERIALS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-05
2 ZHANG Qing-jian, HUANG Tian-hua, XIE Qing-dong, et al (Research Center for Reproductive Medicine, Shantou University Medical College, Shantou 515041, China);Study on Transfection of Mouse Oocytes with Recombinant Plasmid,pBR322-HBV[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-06
3 WANG Shun qing *,HONG Wen de,PENG Ai hua,et al. *Department of Hematology,Guangzhuo First Municipal Peop les Hospital, Guangzhou 510180,P.R.China;Detection of the hypermethylation of calcitonin gene by polymerase chain reaction and its implication in some hematological malignancies[J];CHINESE JOURNAL OF CANCER;1999-06
4 YAN Jian, FANG Yan, HUANG Bi-jun, LIANG Qi-wan, ZENG Yi-xin (Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, P. R. China);Evidence of Genetic Instabilities on Chromosome 16q22-24 in Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2001-06
5 AN Qian, DONG Xiang-yang, ZHANG Jian-jun, HUANG Jin-feng, LI Li, CHENG Shu-jun, GAO Yan-ning (Cancer Institute (Hospital), Peking Union Medical College/ Chinese Academy of Medical Sciences, Beijing 100021, P. R. China);Studies on Inactivation of p16/CDKN2 Gene in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2001-06
6 ZHOU Yong-Ning1, XU Cai-Pu2, HAN Biao1, JI Rui1 1. Center of Endoscopy, The First Hospital, Lanzhou University, Lanzhou, Gansu, 730000, P. R. China 2. Department of Gastroenterology, Southwest Hospital, The Third Military Medical University, Chongqing, 400038, P. R. China;CpG Island Methylation of E-cadherin Gene Promoter in Gastric Carcinoma[J];Chinese Journal of Cancer;2005-10
7 CAO Su-Mei1,2, GUO Xiang1,2, LI Ning-Wei1,2, XIANG Yan-Qun1,2, HONG Ming-Huang1,2, MIN Hua-Qing1,2 1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Clinical Analysis of 1 142 Hospitalized Cantonese Patients with Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2006-02
8 SHEN Rong,TAO Yi-sheng (Department of Pathology,Bengbu Medical College,Bengbu 233030,China);The effects of sodium butyrate on proliferation and apoptosis of esophageal carcinoma Eca-109 cells[J];Journal of Bengbu Medical College;2006-04
9 HUO Li-Jun YANG Zeng-Ming(College of Life Science, Northeast Agricultural University Harbin 150030,China);Progresses on the Methods for Evaluating the Mammalian Sperm Quality[J];Chinese Journal of Zoology;2002-02
10 ZHONG Lan 2,3) LI Wei 3,4) LI Songga ng 2,3,5) ( 2)College of Life Science, Peking University, Bei jing, 100871; 3)Beijing Geno mics Institute, Chinese Academy of Sciences, Beijing, 101300; 4)Laboratory of Bioinformatics, Institute of Biophysics, Chinese Ac ademy of Sciences, Beijing, 100101);Numerous of Conserved Non-coding Sequences in the Pig (Sus scrofa) Genome[J];Acta Scicentiarum Naturalum Universitis Pekinesis;2003-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Shi-Yang Pan,1,2,4 Er-Fu Xie,1,2 Yong-Qian Shu,3,4 Li Gao,1,2 Li-Xia Zhang,1,2 Dan Chen,1,2 Jin-Bu Chen,1,2 Wen-Jun Zhao,1,2 Yuan Mu1,2 and Ji-Nan Zhang41. Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P.R. China 2. The Key Laboratory for Laboratory Medicine of Jiangsu Province, Nanjing, Jiangsu, 210029, P.R. China 3. The Platform for Molecular Diagnosis and Biotherapy of Graveness Disease of Jiangsu Province, Nanjing, Jiangsu, 210029, P.R. China 4. Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, P.R. China;Methylation quantification of adenomatous polyposis coli(APC) gene promoter in plasma of lung cancer patients[J];Chinese Journal of Cancer;2009-04
2 Pu-Yuan Wu,1,2 Yi-Mei Fan1,2 and Ya-Ping Wang1,2 1. Department of Medical Genetics, Medical School, Nanjing University, Nanjing, Jiangsu 210093, P. R. China 2. Jiangsu Key Laboratory of Molecular Medicine, Nanjing, Jiangsu 210093, P. R. China;Germ-line epimutations and human cancer[J];Chinese Journal of Cancer;2009-12
3 GAO Shi-yong,ZOU Xiang,JI Chen-feng,WANG Hong-liang(Postdoctoral Research Station,Inistitute of Materia Medica,Life Science and Enviroment Science Research Center,Harbin Commerce University,Harbin 150076,China);Study of solanine on apoptosis in HepG_2 cell[J];Journal of Harbin University of Commerce(Natural Sciences Edition);2007-06
4 GAO Li1a,1b,PAN Shiyang1a,1b,SHU Yongqian1c,XIE Erfu1a,1b,CHEN Jinbu1a,1b,ZHAO Wenjun1a,1b,MU Yuan1a,1b,ZHANG Lixia1a,1b,CHEN Dan1a,1b,HUANG Peijun1a,1b,ZHANG Jinan2(1.the First Affiliated Hospital of Nanjing Medical University; a. Center of Laboratory Medicine; b. the Key Laboratory of Laboratory Diagnosis of Jiangsu Province; c. Department of Oncology; 2. the Key Laboratory of Biological Diagnosis and Treatment of Jiangsu Province. Nanjing 210029, China);Plasma RASSF1A gene methylation quantification by real-time MSP[J];Chinese Journal of Clinical Laboratory Science;2008-03
5 XU Shuo-qi(Experimental Center of Life Science,Nanjing Agricultural University,Nanjing 210095,China);Epigenetics in Tumor[J];Animal Husbandry and Feed Science;2010-02
6 ZHANG Pei-qi(College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,PRC);The Determinants of Epigenetics of Cancer[J];Hunan Agricultural Sciences;2010-19
7 Xing-Zi Xi Department of Education Sciences,Xinxiang University,Xinxiang 453003,China;Prostate cancer and epigenetic modification[J];Chemistry of Life;2010-03
8 Lü Fang,SU You-hong, ZHANG Fu-chun,LI Jiang-wei (National Key Laboratory of Xinjiang Biology Resources and Genetic Engineering,College of Life Science and Technology,Xinjiang University,Urumqi 830046,China);Survey on active components in plant with antitumor activity by epigenetic modulation[J];Chinese Traditional and Herbal Drugs;2008-10
9 WU Xue-Mei,SHEN Jian-Zhen,YU Ai-Fang,FAN Li-Ping,ZHOU Hua-Rong,FU Hai-Ying,SHEN Song-Fei,WU Dan-SenFujian Institute of Hematology,Union Hospital,Fujian Medical University,Fuzhou 350001,Fujiam Province, China;Detection of APC Gene Promoter Methylation in Hematological Malignant Cell Lines by Nested-Methylation Specific Polymerase Chain Reaction[J];Journal of Experimental Hematology;2009-04
10 PAN Shiyang(Department of Laboratory Medicine,the First Affiliated Hospital of Nanjing Medical University,Jiangsu,Nanjing 210029,China);DNA methylation as a biomarker and its clinical application on molecular diagnosis and treatment[J];Journal of Molecular Diagnostics and Therapy;2009-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved