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《Chinese Jouranal of Sports Medicine》 2002-02
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The Relation of the Change in SOD,MDA and Mitochondrial Membrane Potential to Apoptosis in Hepatocyte of Rats after Swimming Training

Liu Liping, et al.Hebei Physical Education Institute, Shijiazhuang, China 050014  
Objective This paper investigates the hepatocyte apoptosis induced by training. The relationship between apoptosis and the enhancement of capacity, the activity of SOD, the quantity of MDA and the mitochondrial membrane potential and DNA double analysis of hepatocytes in rats was studied. Methods Fifty male SD rats were randomly divided into five groups: G 1 (control group), group G 2 to G 5 (swimming for 1-, 6-, 12-, 18-day, respectively). The rats were forced to swim for thirty minutes and twenty minutes with an interval of forty minutes . Mitochondrial membrane potential in the hepatocyte and DNA double analysis was determined by the flow cytometry. MDA and SOD was determined by sulfobarbituric acid colorimetric analysis and radioimmunity. Apoptosis was observed with JEM-1200EX electric microscope and terminal deoxynucleotidyl transferase mediated d-UTP nick end labeling (TUNEL). Results The mitochondrial membrane potential in hepatocyte increased first, then recovered and increased again. The sub "G 1" peak (apoptosis peak) appeared in all groups. The apoptosis percentage in 6-day group was the highest. The SOD activity increased first, then decreased and increased again. The quantity of MDA significantly increased. Conclusion Exercise could cause the changes in mitochondrial membrane potential, SOD, MDA and DNA double. These changes could induce further hepatocyte apoptosis.
【CateGory Index】: R87
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