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《Chinese Journal of Sports Medicine》 2017-06
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Analysis of Regional Characteristics of Striatal Neurons Activities in Rats with Exercise-induced Fatigue

Hou Lijuan;Cheng Mingchen;Liu Xiaoli;Zhang Jimin;Qiao Decai;College of Physical Education and Sports,Beijing Normal University;  
Objective To observe the local field potential activity of dorsomedial and dorsolater striatal(STR)neurons in rats with exercise-induced fatigue,so as to explore the regional characteristics ofthose neurons. Methods Thirty-six male Wistar rats were randomly divided into a control group(CG),asingle fatigue group(SFG)and a repeated fatigue group(RFG),each of 12. The exercise-induced fatiguemodel was established according to a load-increasing treadmill running protocol. The CG did not doany treadmill running,SFG finished one-time exhaustive exercise while the RFG repeated exhaustive ex-ercise 6 times. The extracellular glass microelectrode technique was used to record the spontaneous fir-ing of dorsomedial(n=6)and dorsolateral(n=6)STR neurons in vivo to observe the discharging frequency,characteristics and types. Results(1)Spontaneous firing frequencies of striatal neurons in SFG were significantly higher than those of CG(P0.01),while those of RFG were significantly lower than SFG.(2)After repeated fatigues,there were significant decreases in the irregular firing pattern and significant increase in the explosive firing of striatal neurons compared with CG(P0.05).(3)After the single fatigue and repeated fatigue,the discharging frequency of dorsomedial medium spiny-like neurons in-creased significantly(P0.05),and that after repeated fatigue significantly higher than that of the dorso-lateral(P0.01). The discharge frequency of the dorsomedial and dorsolateral fast-spiking neurons de-creased significantly after repeated fatigues. The discharge frequency of dorsolateral large aspiny-likeneurons of RFG was significantly higher than SFG,while that of the latter was significantly lower thanCG(P0.05). Conclusions(1)Striatal neurons mediate exercise-induced fatigue and present regionalcharacteristics,which might be due to dorsomedial and dorsolateral striatal neurons receiving differenttypes of projection neurons.(2)Striatal fast-spiking neurons may play an important role in mediating the exercise-induced fatigue.
【Fund】: 国家自然科学基金(31171138/31401018);; 北京市自然科学基金(5142012)
【CateGory Index】: G804.7
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