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Study of Biological Characteristics of Mitochondrial Membrane during Exercise-induced Fatigue Part Ⅲ:Alterations of Activity of NADH-CoQ Reductase of Hepatic Mitochondrial Membrane and Content of Hepatic NAD+ in Rats

 Lu Mei,Zhang Yang,Li Jingxian,et al Institute of Sports Medicine,Tianjin College of physical Edncation  
Using the SD rats with incremental treadmill running as experimental model, the following alterations inSD rats' liver were examined respectively after the exercise: l) The activity of NADH - CoQ reductase inhepatic mitochondrial membrarane(HMM)(complex I);2).The amount of NAD+ in hepatic tissue;3) Thecontent of lipoperoxide(LPO, e.g. MDA content) in HMM. The results showed that, after exercise, theactivity of NADH-CoQ reductase in HMM decreased significantly by 37.3%, so did the NAD+ in liver tissueby 34% (P0.05,respectively). While the content of LPO in hepatic mitochondria increased significantly(P0.01).The.results suggested it might be one of mitochondrial membrane molecular characteristics inexercise-induced fatigue that the HMM complex I damaged and the substrates for respiratory chainaccumulated, and the utilization of oxygen in liver mitochondria decreased during the exhaustive exercise.
【Fund】: 国家体委委管课题
【CateGory Index】: R873
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