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Establishment of model in chronic renal insufficiency of rats

Xiong Zuying, Ding Changhai, Zhang Baike et al (Dept of Nephrology, The 1st Affiliated Hospital of Anhui Medical University,Hefei 230022)  
Objective To establish a special animal model of chronic renal inefficiency (CRI) in Wistar rats. Methods At 1 week after right kidney of rats was removed by operation, some rats were received adriamycin (Adr) twice (5 and 3 mg·kg -1 , respectively) at 3 week intervals. All animals were divided into 4 groups: control, right kidney nephrectomy (RKX), Adr, and CRI. Urinary protein excretion (UPE) of 24 hours in all rats was observed at 2 to 12 weeks, and plasma biochemical parameters and histological examination were investigated at 3rd month. Results In the third month after Adr administration, besides the typical nephrotic syndrome, the levels of blood urea nitrogen and plasma creatinine were increased more ( P 0 01) in group CRI than that in control. The level of osmolality was remarkably decreased. Histologically, mesangial cellularity slightly increased and extracellular matrix significantly expanded in the majority of glomeruli. Tubules showed apparently focal atrophy and many proteincasts were found in dilated tubules. Moderate fibrosis in interstitium was also observed. Conclusion Renal injury may be induced by RKX or Adr administration, and CRI is produced in combination with RKX and Adr administration in three months.
【CateGory Index】: R-332
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