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《Acta Universitis Medicinalis Nahui》 2003-04
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Inactivation of the p16/MTSI gene in bladder cancer

Lu Wensheng, Yu Dexin, Zhou Qing et al (Dept of Biochemistry and Laboratory of Molecular Biology, Anhui Medical University, Hefei 230032 )  
Objective To investigate the inactivation of p16 gene in bladder cancer. Methods The p16 gene was analysed by duplex PCR,PCR SSCP and DNA methylation analysis in 25 bladder cancer tissue samples. Results The gene deletions were found in six samples, the deletion ratio of p16 gene was 24%. No case showed point mutation; 16 cases showed p16 gene 5′ CpG island methylation. Conclusion The deletion of p16 exon 2 is not a frequent event; a statistically significant association is also found between p16 gene 5′ CpG island methylation and the inactivation of p16 gene in bladder cancer.
【Fund】: 国家自然科学基金(编号 :3 9870 3 2 4);; 安徽省自然科学基金(编号:0 10 43 716和990 44 3 12 );; 安徽省教育厅自然科学基金(编号:JL 96 0 77);; 安徽省学术带头人研究基金资助
【CateGory Index】: R737.14
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【Citations】
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【Co-citations】
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1 YAO Qing-Jun 1,CHEN Bi 1,HU Da-Hai 1,XU Ming-Da 1,DONG Mao-Long 1,WANG Shu-Sen 2 1Department of Burn Surgery, 2Department of Orthopedics,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Methylation control of p16 gene expression in early phase of deep second degree burn and hypertrophic scar after burn healing[J];Journal of The Fourth Military Medical University;2005-04
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