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《Acta Universitis Medicinalis Nahui》 2004-02
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Effect of astragalus polysaccharides on IL-1,NO and TNFα secreted by lipopolysaccharide-induced normal rat peritoneal macrophages

Lu Jingtao, Yang Yan, Chen Minzhu (Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032)  
Objective To study effect of astragalus polysaccharides (APS) on IL-1,NO and TNFα secreted by normal rat peritoneal macrophages (PMΦs) induced by lipopolysaccharide (LPS). Methods Rat peritoneal macrophages were stimulated with 10 mg/L LPS in vitro. TNFα production was measured by assay of cytotoxicity against L929 cells,production of NO was determined by Griess assay,activity of IL-1 was assayed by [ 3H] TdR. Results APS could markedly inhibit production of NO,TNFα and IL-1 of PMΦs induced by LPS. Conclusion Inhibiting direct secretion of NO,TNFα and IL-1 produced by PMΦs might be one of the mechanisms of hepatoprotective effect of APS.
【CateGory Index】: R285
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