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《Acta Universitis Medicinalis Nahui》 2004-05
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Protective effect of total glycosides of Zhizi on experimentalacute gastric mucosal lesion induced by aspirin

Ma Yan, Jin Jiahong, Zhao Weizhong et al(Dept of Pharmacology , Anhui Medical University,Hefei 230032)  
Objective To study the protective effect of total glycosides of Zhizi (TGZ) on experimental acute gastric mucosal lesion induced by aspirin in rats.Methods We used aspirin intragastric injection to make the model of acute gastric mucosal lesion (AGML) , measured the lesion index of rats in TGZ (140,70,35 mg/kg) and control groups. The activity of superoxide dismutase (SOD) and Malonyl dialdehyde (MDA) level in blood and gastric mucosal blood flow (GMBF) were determined as well.Results Gastric mucosal lesion index of all the TGZ dosage groups was obviously reduced as compared with the control group. GMBF was significantly increased. TGZ increased SOD activity but reduced MDA content. Conclusion TGZ can inhibit aspirin-induced gastric mucosal lesion, the mechanism may be related to increase GMBF and antioxidation.
【CateGory Index】: R96
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