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《Acta Universitis Medicinalis Nahui》 2005-05
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Protective effect of extract of astragalus against focal cerebral ischemia-reperfusion injury

Cao Xi,Li Weiping, Wang Shaobin et al (Dept of Pharmacology, Anhui Medical University, Hefei 230032)  
Objective To study the protective effects of extract of astragalus (EA) against focal cerebral ischemia-reperfusion injury in rats. Methods Middle cerebral artery occlusion(MCAO) was used to make focal cerebral ischemia-reperfusion model by intravascular nylon filament occlusion. Neurological function score, infarction volume and water content of brain in rats after focal cerebral ischemia-reperfusion were measured. The changes of histopathology and blood rheology were detected. Results Compared with model group, EA(20,40,80 mg/kg) decreased the neurological function score. EA decreased the water content and infarction volume of brain in rats after focal cerebral ischemia-reperfusion and improvement in histopathologic examination was observed. EA(80 mg/kg) inhibited the increasing of the blood viscosity, high shear rate reduced viscosity, high shear relative reduced viscosity and low shear relative reduced viscosity. Conclusion EA has protective effects against cerebral ischemia-reperfusion injuries. The mechanism may be related to inhibit the increasing of the blood rheology.
【Fund】: 安徽省十五科技重点专项(编号:01803016);; 安徽省自然科学基金(编号:00144414)资助项目
【CateGory Index】: R285
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