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《Acta Universitis Medicinalis Nahui》 2005-06
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Effects of extract of astragalus on IL-1β,TNF-α and IL-6 expressions after global cerebral ischemia and reperfusion

Li Jing, Ming Liang, Huang Rongrong(Dept of Pharmacology, Anhui Medical University, Hefei 230032)  
Objective To explore the protective effects of extract of astragalus on inflammatory injury after global cerebral ischemia/reperfusion in rats. Methods The model of global cerebral ischemia/reperfusion was established with four vessel occlusion method(4-VO). Sprague-Daewley rats were randomly divided into therapy groups, shame operation group and ischemia/reperfution group. Vertical screen test and beam balance test were used to evaluate the rats′ behavioral function at 12 h and 24 h after reperfusion. After global cerebral ischemia/reperfusion, the rats′ serum and cortex IL-1β, IL-6 and TNF-α were detected with radio-immuno-assay. Results Compared with ischemia/reperfusion group,serum and cortex IL-1β,IL-6,TNF-α of EA (40,80 mg/kg) group declined significantly after global cerebral ischemia/reperfusion.Behavioral function of EA group after 24 h reperfusion was improved to some extent. Conclusion EA has protective effects on cerebral ischemia which is related to inhibition of cytokine expression.
【Fund】: 安徽省十五科技重点专项(编号:01803016);; 安徽省自然科学基金(编号:00144414);; 安徽省教育厅高校省学术带头人后备人选科学研究资助项目(编号:2005HBZ18)
【CateGory Index】: R285.5;
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