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《Acta Universitatis Medicinalis Anhui》 2006-04
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The antitussive,expectorant and anti-asthmatic activities of triterpene acids of loquat leaves in mice and guinea-pigs

Ge Jinfang, Li Jun, Jin Yong, et al (School of Pharmacy, Anhui Medical University, Hefei 230032)  
Objective To study the antitussive, expectorant and anti-asthmatic effects of triterpene acids of loquat leaf (TAL) . Methods Cough was induced by ammonia water in mice and acid citric in guinea pig. Excretion function of the airway in mice was determined by phenolsulfonphthalein method. Anti-asthmatic effect was observed through both the guinea pig model induced by the mixture of histamine phosphate and acecolex and the amounts of bronchoalveolar lavage in vitro. Results TAL (75,225,675 mg/kg, ig) not only prolonged the cough latent period and decreased the frequency of cough in mice, but also promoted phenolsulfonphthalein excretion. Morever, TAL (45,135,405 mg/kg, ig) prolonged the cough latent period and asthma incubation period, reduced the cough frequency, and increased the bronchoalveolar lavage amounts of guinea-pigs. Conclusion On the basis of its significant effects on relieving cough, eliminating phlegm and lessening asthma, TAL can be recommend as a remedy of airway diseases.
【Fund】: 安徽省“十五”重大专项课题(编号:a01803010);; 国家自然科学基金资助项目(编号:30771766)
【CateGory Index】: R285
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