Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Universitatis Medicinalis Anhui》 2006-06
Add to Favorite Get Latest Update

Research on methylation of p16 gene in non-small cell lung cancer

Wang Yasong,Jin Yongtang,Xue Shaoli,et al(School of Public Health, Anhui Medical University, Hefei 230032)  
Objective To study the effect of p16 gene methylation in non-small cell lung cancer and correlative factors and to explore the mechanism of lung cancer. Methods The methylation-specific PCR(MSP) was used to[FQ(9。46,X-WZ][CD44] test the methylation status of DNA from 47 lung cancer tissues and corresponding nomalignant tissues, meanwhile data of environment exposure such as smoking was collected. Results The total frequency of p16 methylation was 44.7% in lung cancer tissues, significantly higher than that in the nomalignant tissues 17%(P0.01), p16 methylation was more seen in squamous cell carcinomas(P0.05), there was a statistic difference of methylation frequency between lung cancer tissues and nomalignant tissues in squamous cell carcinomas(P0.01), and methylation significantly correlated with smoking in squamous cell carcinomas(P0.01).Conclusion Methylation of p16 gene may be involved in the progress of squamous cell carcinomas,and be related with smoking/side effect.
【Fund】: 国家自然科学基金资助项目(编号:30471427)
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved