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《Acta Universitatis Medicinalis Anhui》 2007-04
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The protective effects of total flavonoids Chrysanthemum indicum on CCl_4-induced acute liver injury in mice

Zhang Ling,Li Jun,Wang Jianqing,et al(School of Pharmacy, Anhui Medical University,Hefei 230032)  
Objective To study the protective effects and mechanism of total flavonoids Chrysanthemum indicum(TFC)on CCl4-induced acute liver injury in mice.Methods The animal model of acute liver injury was estab-lished by0.1% CCl4(10 ml/kg,ip).To evaluate the hepatic injury of these animals,we observed changes of hepa-tocytes through (pathological section,tested the serum transaminases(ALT,AST) activity,and detected hepatic tis-sue MDAcontents and SOD activities.The mechanism of TFC on acute liver protection was analyzed the expressionof TNF-αby the method of Radioimmunoassay.Results TFC could significantly decrease the activities of serumALTand AST. MDAcontents dropped markedly and SOD activities increased greatly. Pathohistological observationindicted the liver lesion was markedly alleviated.The liver protective mechanism of TFC might be related with de-creased expression level of TNF-α.Conclusion TFC has protective effects on CCl4-induced acute chemical liverlesion, the mechanism might be related with scavenging free radical,resisting lipid peroxidation and decreasing ex-pression level of TNF-α.
【Fund】: 国家重大基础研究前期研究专项资助项目(编号:2002CC02900)
【CateGory Index】: R285.5
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