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《Acta Universitatis Medicinalis Anhui》 2008-04
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Effects of astragalus extract on NFκBp65,ICAM-1 and TNF-α expression after global cerebral ischemia and reperfusion in rats

Wu Guocui,Li Jing,Li Weiping,et al(Dept of Pharmacology,Anhui Medical University, Hefei 230032 )  
Objective To explore the mechanisms of neuro-protection effects of astragalus extract(EA) in global cerebral ischemia and reperfusion (I/R) rats.Methods Rats were pretreated ig EA for 5 d and then subjected to global cerebral I/R by four-vessel occlusion method.Expressions of NFκBp65, IκBα in cortex tissue of I/R rats were evaluated with Western blot, and the expressions of ICAM-1 and TNF-α of the cortex tissue were examined by immunohistochemical technical in I/R rats.Results EA increased the expressions of neucleoprotein NFκBp65 (107.1±24.18 vs 313.09±23.35,P0.05) and decreased the expression of plasmosin NFκBp65 (221.72±19.44 vs 125.82±25.07,P0.05),IκBα (382.98±55.21 vs 184.37±20.40,P0.05).Compared with control group,ICAM-1 and TNF-α expressions during I/R of the group treated with EA were significantly decreased.Conclusion EA has protective effects on cerebral injury through inhibiting the activation of NFκB and decreasing the cortex expressions of ICAM-1 and TNF-α after I/R injury.
【Fund】: 安徽省十五科技重点专项(编号:01803016);; 安徽省自然科学基金项目(编号:00144414);; 安徽省教育厅高校省学术带头人后备人选科学研究资助项目(编号:2005HBZ18)
【CateGory Index】: R285.5
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