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《Acta Universitatis Medicinalis Anhui》 2009-05
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Relationship between nocturnal hypoxemia and sleep stages in chronic obstructive pulmonary disease,and the outcome of different treatments

Ding Zhen,Li Xiu,Wang Tong,et al(Dept of Respiratory Medicine,Third Affiliated Hospital of Anhui Medical University,Hefei 230061)  
Objective To analyze the relationship between sleep-related oxygen desaturation and sleep stages in chronic obstructive pulmonary disease(COPD) patients with nocturnal hypoxemia,and evaluate different treatments of nocturnal hypoxemia.Methods All of the 27 cases were clinically diagnosed as COPD patients with nocturnal hypoxemia.These cases were randomly assigned to two groups,12 cases were treated by non-invasive positive pressure ventilation(NIPPV),and the other 17 cases were treated by continuous low flow oxygen inhalation.Results Nocturnal hypoxemia intensified at deep sleep stages(stage 3,stage 4 and the REM stage),the heart rate and artery pressure were increasing in deep sleep stages(to compare with stage 1 and stage 2,P0.05).NIPPV could improve the nocturnal SaO2 level in COPD patients with nocturnal hypoxemia,continuous low flow oxygen inhalation could also improve the nocturnal SaO2 level,but got a unsatisfactory treatment outcome in the patients with daytime hypoxemia(to compare with NIPPV,P0.05).Conclusions In order to improve the nocturnal SaO2 level in COPD patients with nocturnal hypoxemia,adequate treatment may be administrated based on pathognostic patient′s conditions.
【Fund】: 合肥市科研基金项目:合科【2006】46号序号58
【CateGory Index】: R563.9
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