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《Acta Universitatis Medicinalis Anhui》 2013-08
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Study on genetic toxicity of glycosides of chaenomeles speciossa

Lu Jingtao,Wei Wei(Institute of Clinical Pharmacology of Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine(Anhui Medical University),Ministry of Education,Anhui Traditional Chinese Medicine Research and Development Key Laboratory,Hefei 230032)  
Objective To assesse the effect of glycosides of chaenomeles speciossa(GCS) on genetic toxicity.Methods Ames test,micronucleus test in mouse bone narrow and CHL cell chromosome aberration test were carried out respectively.Results GCS(62 ~ 5 000 μg / plate) with or without hepatic microsomal enzyme S9 mix could not induce reverse mutagenicity to four auxotrophic mutants TA97,TA98,TA100 and TA102.At the same time,GCS(31.3,62.5,125 μg/ml) with or without S9 mix could not evocate CHL cell chromosomal aberration in structure and number either,and other GCS(312.5,1 250,5 000 mg / kg) was administrated to the mice,compared with vehicle control,sum of MN and MN rate in mice bone narrow did not increase significantly.Thus all results were negative.Conclusion GCS has no effects on gene mutation and chromosomal aberration.
【Fund】: 安徽省十五重大科技专项(编号:01803026);; 安徽高校省级自然科学重点项目(编号:KJ2012A160)
【CateGory Index】: R285
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