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《Jiangsu Medical Journal》 2012-06
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Rosewood essential oil relieving depression-like behaviors and neurotransmitters via olfactory pathway

CHEN Jun,XU Jinyong,XU Rong,et al. Department of Neurobiology,Anhui Medical University,Hefei 230032, CHINA  
Objective To evaluate the feasibility and possible mechanism that rosewood essential oil(REO) can improve depression-like behaviors of mice. Methods With chronic unpredictable moderate-intensity stimulation(CUMS) with isolation,the depression-like model was established in 48 male C57 BL/6 mice.The depressed mice were randomly divided into 4 groups of A(the controls),B(CUMS plus REO sniff),C(CUMS plus fluoxetine) and D(CUMS alone).The neurological behavior was recorded and dopamine(DA) in the brain was detected using immunohistochemical method before and after modeling. Results Compared to group D,on the 2nd,3rd and 4th week of the treatment,the times of immobility in tail-suspension test and forced swimming test were all significantly shortened and consumption of sweet water was remarkably increased(P0.05). The expression of DA in the hippocampus,hupothalamus and amygdala after sniff treatment was higher in groups of B and C than that in group D. Conclusion REO can attenuate the depression-like behaviors in depressed mice models,which may be through the regulation effect of REO on the central nervous system via olfactory pathway.
【Fund】: 国家自然科学基金(81000589);; 安徽医科大学校基金(2011xkj007)
【CateGory Index】: R285
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