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《Chinese Journal of Organic cHEMISTRY》 1993-03
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Synthesis of 1-Aroyl-3-(4-Benzosulfonamidopyrimidine)-thioureas

JIA Xue-Shun;WANG Yu-Lu;LI Yong-Fang;HE Fang-Shu;SHAN Ying-Fang Department of Chemistry, Henan Normal University, 453002 Xinxiang, Henan Department of biology, Henan Normal University, 453002 Xinxiang, Henan  
A series of new 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas(1a~1) were syn-thesized by the reaction of aroylisothiocyanate with sulfadiazine in anhydrous acetonitrile. Preliminarybiological tests indicate that some of compounds (1a~1) possess marked inhibiting activity againstcolibacillus, Bacillus subtilis, proteus and Staphylococcus aureus at concentration of 10ppm.
【Fund】: 河南省科委自然科学基金
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