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《Chinese Journal of Organic Chemistry》 2006-11
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Research Advances in Microwave-Assisted Combinatorial Synthesis

ZHOU, Zhong-Zheng HE, Yan-Zhen CAO, Min YANG, Guang-Fu (Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079)  
The technique of microwave-assisted combinatorial synthesis, which developed recently from the combination of microwave-assisted organic synthesis with combinatorial synthesis, has been widely applied by medicinal chemists and become one of the most powerful tools to improve the efficiency of drug development. In this paper, the recent developments of microwave-assisted combinatorial synthesis are reviewed including solid phase synthesis, application of polymer-supported catalyst to combinatorial synthesis, liquid phase combinatorial synthesis, fluorous phase combinatorial synthesis and combinatorial parallel synthesis.
【Fund】: 国家自然科学基金(Nos.20432010 20476036 20172017 20203009);; 教育部跨世纪优秀人才;; 教育部重点科技项目(No.104205);; 湖北省自然科学基金优秀群体(No.2004ABC002)资助项目.
【CateGory Index】: O644.2
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