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《Chinese Journal of Organic Chemistry》 2013-05
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Synthesis and Antifungal Activity of Novel 1-(3-Indoly)3-aryl-2-propen-1-one Oxime Ethers

Wang,Meiyan Qu,Zhiqiang Du,Dan Jiang,Lin*(College of Chemistry and Material Science,Shandong Agricultural University,Taian 271018)  
With the aim of finding novel indole derivatives with high antifungal activity,3-acetyl indole was prepared using indole and other chemicals as starting materials through the Vilsmeier reaction,followed by reactions of aldol condensation and addition-elimination to synthesize a series of novel 2-propen-1-one oxime ethers containing indole moiety 3a~3j,and their structures were elucidated by IR,1H NMR,MS techniques and elemental analysis.The target compounds were tested for in-vitro antifungal activities against Botrytis cinerea and Anthracnose pathogen by the mycelium growth rate method,and the result indicated that 3f and 3g displayed good antifungal activity against Botrytis cinerea at a concentration of 100 μg/mL,with inhibition rates of 81% and 74%,respectively.
【Fund】: 山东省自然科学基金(No.ZR2009BM044)资助项目~~
【CateGory Index】: O626
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