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《Chinese Journal of Organic Chemistry》 2013-10
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Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids

Yang,Jinhui;Xie,Yimin;Feng,Shangbiao;Zuo,Wubiao;Chen,Bingbing;Ma,Xiaoqin;Feng,Yao;State Key Laboratory Cultivation Base of Natural Gas Conversion,Ningxia University;  
Abyssinone-V, 4'-hydroxy-6,3',5'-triprenylisoflavonone, abyssinone-VI and abyssinone-IV were all isolated from the genus erythrina. This study completed the first total synthesis of four natural prenylated flavanoids by using simple and facile approaches. The result of their in vitro antibacterial tests indicated that all of them displayed moderate bacteriostatic activities. The compounds abyssinone-IV and abyssinone-V showed remarkable antibacterial activities. The structures of all new compounds have been confirmed by HRMS, 1H NMR and 13C NMR spectra.
【Fund】: 国家自然科学基金(No.21162021);; 教育部“新世纪优秀人才支持计划”(No.NCET-09-0860)资助项目~~
【CateGory Index】: O621.3;R284
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