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《Journal of Youjiang Medical University for Nationalities》 2019-06
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Analysis of clinical manifestations and laboratory tests characteristics of purulent meningitis in neonates

Wang Huawei;Wu Zhixin;Zhu Xueping;Children's Hospital of Soochow University;  
Objective To explore the clinical manifestations and laboratory test characteristics in neonatal purulent meningitis in order to provide the evidences for early diagnosis and appropriate treatment. Methods The clinical records of 186 neonates diagnosed with neonatal purulent meningitis and admitted to the Neonatal Department of Children's Hospital of Soochow University from January 2010 to December 2016 were reviewed retrospectively. The patients were divided into positive cerebral spinal fluid(CSF) bacterial culture group(n=72) and negative CSF bacterial culture group(n=114) according to the results of CSF bacterial culture. The characteristics of clinical data and laboratory tests in the two groups were compared and analyzed. Results The average age of onset in the positive CSF bacterial culture group [(16.87±9.11) days] was obviously older than that of the negative CSF bacterial culture group [(13.82±10.29) days](P0.05). The peak fever in the positive CSF bacterial culture group [(39.05±0.95)℃] was higher than that of the negative CSF bacterial culture group [(38.56±1.03)℃](P0.05). The average fever course in the positive CSF bacterial culture group [(5.59±4.06) days] was longer than that of the negative CSF bacterial culture group [(3.94±3.53) days](P0.05). Compared to the negative CSF bacterial culture group, neonatal patients in the positive CSF bacterial culture group had higher incidences of both gaze and seizure symptoms(P0.05). Neonatal patients in the positive CSF bacterial culture group had higher peripheral blood C-reactive protein(CRP), higher CSF white blood cell count, higher CSF protein amount and lower CSF glucose concentration than those in the negative CSF bacterial culture group(all P0.05). Comparison of complications and hospitalization duration between the two groups showed that the positive CSF bacterial culture group had higher incidences of subdural effusion and hydrocephalus and longer hospitalization duration than the negative CSF bacterial culture group(P0.05). Conclusion The attack day-age is older in neonatal patients in positive CSF bacterial culture group. Neonates in the positive CSF bacterial culture group are more likely to present high peak fever, long fever process, gaze, seizure, elevated peripheral blood CRP, high CSF white blood cell count, increased CSF protein concentration and decreased CSF glucose concentration, furthermore, longer hospitalization duration and higher incidence of brain MRI abnormalities.
【Fund】: 国家自然基金面上项目(81771626);国家自然基金面上项目(81971423);; 江苏省妇幼健康重点人才项目(FRC201731)
【CateGory Index】: R722.1
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【Citations】
Chinese Journal Full-text Database 5 Hits
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【Co-citations】
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1 Shi Kaili;Du Donghai;Yang Yinsheng;Zhang Linxia;Zhang Yanzhi;Han Hong;;Clinical analysis of Listeria monocytogenes meningitis in 11 neonates[J];国际儿科学杂志;2018-10
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