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Andrographis paniculata Nees Augments the Therapeutic Effects of Cyclophosphamide on Murine Sarcoma 180

Wang Kun Huang Laqing Zhou Linyuan She Shangyang Zhao Lijuan Department of Microbiology. Youjiang Medical College for National minorites,Bose,Guangxi,China  
esults of experimenting with extract of Andrographis paniculataNees(APN)on mice indicated that effects of the extract of APN,which containschiefly fiavones,on mice were investigated.No anti-tumoreffect was foundwhen APN was administered alone.Cyclophosphamide(Cy)could inhibit tu-mor growth by 89.56%;and the inhibility reached 95.16% when APN and Cywere given simultaneously(P0.02).The results indicated that APN could en-hance the therapeutic effect of Cy in murine S180.Effects of APN on the whiteblood cell(WBC)counts in peripheral blood of tumor-bearing mice were alsostudied.It was shown that APN could antaganize the decrease in WBC countsinduced by Cy,suggesting that APN could diminish the hemopoietic damagecaused by Cy.
【CateGory Index】: R282.710.7
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