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《Chinese Computed Medical Imaging》 2016-04
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Value of DWI at 3.0T MRI in Predicting Hemorrhagic Transformation after Acute Ischemic Stroke in Rabbits

HUA Rong;SHI Yi-bing;XU Kai;WANG Tao;Department of Radiology, Xuzhou Central Hospital;Department of Radiology, Affiliated Hospital of Xuzhou Medical College;  
Purpose:To assess the value of apparent diffusion coefficient(ADC) and exponential apparent diffusion coefficient(e ADC) value of diffusion weighted imaging(DWI) in predicting hemorrhagic transformation(HT) after acute ischemic stroke in rabbits. Methods:Autologous thrombus was injected into unilateral internal carotid arteries of 37 New Zealand white rabbits to set up acute ischemic stroke model. These rabbits were undergone DWl on a 3.0T machine at 3.5 hours after operation. Thrombolytic therapies were carried out with urokinase at 4.0 hours after arterial occlusion. Rabbits were killed after the end of all scanning. Their brains were extracted and microscopic histological exams were done. The HT rabbits were classified into non-HT and HT group. The differences of ADC and e ADC between non-HT and HT group were assessed by using SPSS 16.0 software, P0.05 was considered to indicate statistical significance. Results:Acute ischemic stroke model was successfully set up in 27 rabbits. There were 6 rabbits who had HT included 5 rabbits with HI and 1 with PH. The ADC value of HT group was(0.482±0.068)×10-3mm2/s, the non-HT group was(0.752±0.114)×10-3mm2/s. There were statistical significant differences between non-HT and HT group in ADC values(P=0.000). The e ADC value of HT group was 0.618±0.074, non-HT group was 0.479±0.053. There was statistical significance between non-HT and HT group in e ADC value(P=0.000). Conclusion:There is correlation between the decrease of ADC, the increase of e ADC and the occurrence of HT in acute ischemic stroke.The changes of e ADC and EDC value can be used to predict HT, which may provide important information for thrombolysis therapy.
【Fund】: 徐州市科技计划项目KC14SH019~~
【CateGory Index】: R445.2;R743.3
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