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《Modern Chinese Medicine》 2015-04
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Purification of High Purity Stilbene Glycosides from Polygonum multiflorum

LI Yao;GUAN Shuyu;LI Jiang;WANG Qun;DENG Wanting;School of Traditional Chinese Medicine,Guangdong Pharmacutical University;  
Objective: To find a new system of HSCCC solvent rario for purification of high purity stilbene glycosides from Polygonum multiflorum.Methods: The crude extract of P.Multiflorum was preliminary purified under the optimized weak alkaline.And the crude product of stilbene glycosides has been further purified by HSCCC.Result: The purity of stilbene glycosides crude product reached 96%.The stilbene glycosides further purified by HSCCC reach 99%.Conclusion: The high purity silbene glycoside could be isolated and purified by taking advantage of the stability of stilbene glycosides could under weak alkaline condition.The method could avoid adsorption loss and large solvent consumption in column chromatography like macroporous resin,and non-crystallizable stilbene glycosides,and the method provide a effective way to produce high purity stilbene glycosides in large scale.
【Fund】: 国家自然科学基金(81001702);; 省部产学研结合项目(2010B090400519);; 广东药学院人才启动基金(2007ZYX01);; 广东省大学生创新训练计划项目(1057312033)
【CateGory Index】: R283.6
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