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《Chinese Journal of Pharmacology and Toxicology》 1986-01
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Influence of gypenosides on immunological function in rodents

QIAN Bo-chu, ZANG Xing-xing, CHEN Jue, XU Heng-jun, LIU Xue-li, YUAN Yu-ying, PENG Xiao-ying(Department of Pharmacology, Institute of Materia Medica, Zhejiang Academy of Medicine, Hangzhou 310007)  
The effect of gypeno-sides extracted from Gynostemma pentaphyllum Makino on immuno-logical functions was investigated in mice and rats.The results showed that gypeno-sides at the dose of 400 mg/kg given orally for 5 days significantly prevented the reduction of serum hemo-lysin production in primary response to sheep red blood cell (SRBC) in mice induced by a sc injection of cyclophosphamide 75 mg/kg. In mice bearing Sarcoma-180 and dexametha-son-treated rats (10 mg/kg sc injection for 5 days) gypenosides given orally prevented effectively the decrease of the number of spleen PFC, SRFC and QHS at the dose of 400 mg/kg and 150-300 mg/kg for 12 and 15 days, respectively.It is concluded that gypenosides possess immunoenhancing functions in immunosuppressive agent treated or tumor bearing rodents.
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