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《Chinese Journal of Pharmacology and Toxicology》 1988-02
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Effect of Lyeium barbarum polysaccharides (LBP) on immune function of S180-bearing mice and theirantitumor activity

WANG Bai-kun, XING Shan-tian, ZHOU Jin-huang, GENG Chang-shanInstitute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850  
The relative proliferation index (RPl) of the splenic T lymphocytes of mice bearing SI 80 tumor was higher than normal control level (100%), i.e. 166 % on d 2 and 390 % on d 4. It was decreased to 20 % on d 6, and 11.5 % on d 9. The suppressed of RPI was raised from 0.3 % to 24.6 % by 10 mg/(kg.d) LBP from d 2 to 9. Daily dose of LBP 10-20 mg/kg could also inhibit tumor growth-by 31-39 %. Combination of cyclophosphamide (Cy)and LBP increased the inhibition of tumor weight about three folds over that of Cy alone, i.e., 54% and 14%, respectively. These rest Its indicated that LBP could both augment the cellular immune function and inhibit tumor growth in S180 tumor bearing mice.
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