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《Chinese Journal of Pharmacology and Toxicology》 1989-01
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Immuno-pharmacological effects of Bupleurum chinense polysaccharide

ZHANG Xing-quan,CHEN Hong-shan(Dept of Virology,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences,Beijing 100050)  
Balb/c mice were injected intraperitonealy with Bupleurum chinense polysaccharide (BCPS)100mg/kg.Significantly enhanced spleen weight/10 g body weight and peritoneal macrophage phagocytosis were noted.Specific anti-influenza virus antibody (IgG)titers were raised 2-4 times,but no significant differences were showed in the hemolysin production secreted by spleen cells.BCPS did not affect the delayed type hypersensitivity in normal mice,but it markedly restored the DTH response in the immunosuppressive mice treated with cyclo-phosphamide or influenza virus.BCPSincreased the lymphocyte transformation activated with Con A and also enhanced NK cell function significantly.These results suggest that BCPS may be an effective immunostimulating agent and it can restore and enhance the humoral and cell-mediated immunity.
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