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Effects of Lycium barbarum polysaccharides and their combination with Corynebacterium parvum on the tumoristatic activity of peritoneal macrophages in mice

ZHANG Yong-xiang,XING Shan-tian,ZHOU Jin-huang( Inst Pharmacology and Toxicology,Academy of MilitaryMedical Sciences,Beijing 100850 )  
Lycium barbarian polysaccharidcs(LBP)extracted from Lycium barbarum L.is a tonic with potentiating effect on cellular immunological functions.In our experiments,we found that LBP could increase tumoristatic activity of peritoneal macrophagcs(Mφ)treated with Con A in vitro against P815 cells.LBP(5,10,20,40 mg/kg)combined with a low dose of Corynebacterium parvum(CP)expressed a synergistic effect on the cytostatic activity of Mφ against both P815 and P388 cells.The maximal effect was observed when the dosage of LBP was 20 mg/kg.The cytostasis(%)of Mφ against P815 and P388 cells were 85.5 and 63.6,while 28.1 and 24.0 in CP controls respectively.The results indicated that LBP could activate peritoneal Mφ of mice to a certain extent and LBP combined with a small dose of CP showed a synergistic effect which was helpful to augment tumoristatic activity of Mφ and to decrease the toxic action of CP,thereby suggesting a new way in immunothcrapy of cancer.In addition,Mφ obtained from C57BL/6 mice immunized with P815 cells(immune-Mφ)showed obviously cytostatic activity to P815 cells and such activity of immune-Mφ was markedly intensified by LBP.
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