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《Chinese Journal of Pharmacology and Toxicology》 1990-01
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Effect of Lycium barbarum polysaccharides on the immune responses of T,CTL and NK cells in normal and cyclophosphamide-treated mice

WANG Bai-Kun,XING Shan-Tian,ZHOU Jin-Huang (Inst Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850)  
LBP(Lycium barbarum polysacch-arides,extracted from the fruit of Lycium barbarum)5 or 10 mg/(kg·d),ip,could increase T lymphocyte proliferation.LBP 5 mg/(kg·d),ip,could enhance the cytotoxicity of CTL and NK cells.LBP 5 or 10 mg/(kg·d),ip,could antagonize the suppressive effect of cyclophosphamide(Cy)on T lymphocyte proliferation.Inhibitory rates of CTL cytotoxicity were decreased from 51 % in Cy control mice to 19 % and 36 % in LBP-treated Cy mice.Furthermore,administration of LBP 10 or 20 mg/(kg·d)restored the reduced NK cell cytotoxicity caused by Cy administration in mice.These results provide evidence of protective effect of LBP in augmenting T-cell-mediated immunity and NK cell activity in normal and cyclophosphamide treated mice.
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