Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmacology and Toxicology》 1990-01
Add to Favorite Get Latest Update

Effects of gypenosides on platelet aggregation release and cAMP level in rabbits

WU Ji-Liang,QIU Pei-Lun,LIU Jun-Tian,MU Qi-Yun,XIN Dong-Sheng (Dept Pharmacology,Xian Medical University,Xian 710061)  
The antiplatclet aggregation effect of gypenosides(GPs)extracted from Gynoslemma pentaphyllun(Thnb.)Mak.was studied in platelet-rich plasma(PRP)of the rabbit by Bern's turbidometry.GPs inhibited platelet aggregation induced by threshold concentration of ADP,arachidonic acid and collagen in a dose-dependent manner in vitro and IC50 was about 0.49,0.47 and 0.50mg/ml,respectively.GPs(40 mg/kg)also inhibited platelet aggregation in vivo,approximately lasting for 60 min and its maximal inhibition rate for ADP,arachidonic acid and collagen was 32.6,39.6 and 35.7%,respectively.The most powerful action occured at 5 min after giving GPs.In order to study its antiplatelet mechanism,effects of GPs on platelet serotonin release and cAMP level were further studied in PRP of therabbit by fluorescence spcctrophotomctry and in washed platelet suspension of the rabbit by radioimmunoassay,respectively.GPs and aspirin both inhibited platelet serotonin release induced by collagen with inhibition rate of 87.1 and 91.7% at 1.00 mg/ml,respectively.GPs also significantly increased the platelet cAMP level,with increasing rate of 200% at 1.00 mg/ml.The results suggest that GPs is a potent inhibitor to platelet aggregation and its action mechanism may related to inhibiting the platelet from releasing reaction and increasing the platelet cAMP level
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 8 Hits
1 HOU Xiao-Ping; JIA Guo-Liang; ZhAOKuan; JIA Guang-Xing;; DA Ji-Ping(Department of Cardiovasology, Xijing Hospital,Fourth Military Medical University, Xi'an 710033)(General Hospital of Air Force,PLA);Effects of gypenosides on intimal proliferation and expression of c-sis oncogene in rabbit iliac artery afterballoon deendothelialization[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-05
2 Yu Juan;Yang Shanzhang(Department of Pathophysiology,Fujian Medical College,Fuzhou,350004);Observation of Effects of Gynostemma Pentaphyllum on Platelet Disaggregation in Human[J];;1995-03
3 SunAixun;Research Reviews of Pharmacological Studies of Chinese Materia Medica on lnfluencing the Cercebral Circulation[J];Liaoning Journal of Traditional Chinese Medicine;1990-12
4 Pu Jiakang, et al. Department of Pharmacology, Nanjing Railway Medical College (210009);Effects of Gypenosides on Cardiac Function in Ischemic Myocardia of Rats[J];Railway Medical Journal;1991-04
5 WANG Zhu-Yun, QIU Pei-LunDepartment of Pharmacology, Xi'an Medical University, Xi'an 710061;Protective effect of gypenosides on acute incomplete cerebralischemia in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1992-03
6 Hou Xiaoping ,Jia Guoliang,Zhao Kuan,et al;Effects of gypenosides on intimal proliferation and expression of c sis oncogene in rabbit iliac artery after balloon deendothelialization[J];JOURNAL OF GENERAL HOSPITAL OF AIR FORCE,PLA;1998-02
7 WANG Aiping,WEI Qingmin,CHEN Shuzhen,et al.Xingtai People′s Hospital in Hebei Province,Xingtai Hebei 054031;Clinical and experimental study of Xintai capsule(心泰胶囊) on angina of coronary atherosclerosis heart disease[J];INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE IN PRACTICE OF CRITICAL CARE MEDICINE;2000-03
8 LIU Gui lan 1,XU Zhi hua 2 (1? Department of Physiology,Bengbu Medical College;2 ? Department of Quality Control,The Third People's Hospital of Bengbu City,Bengbu 233003);Study of the effect of meglumine cyclic adenylate on platelet function of rats[J];Chinese New Drugs Journal;2001-01
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Jili; Huang Yifeng;et al.(Hangzhou Institute of Materia Medica,Hangzhou,310023,Zhongkai College of Agricultural Technology,Guangzhou, 510225);Comparison of Determination Methods for Gypenosides[J];CHINESE TRADITIONAL PATENT MEDICINE;1995-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Du Yangyang and Mo ZiyaoGuangzhou Anti-epidemic Station,Guangzhou 5l0080;STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC POTEN-TIALS OF GYPENOSIDES(GPS)IN MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1995-03
2 LIU Xia,WANG Ping-jun,Xu Fu-xin (The Frist People's Hospital of Wuhu,Anhui Wuhu 241000,China);STUDY ON GYPENOSIDES INHIBITING NEOPLASM GROWTH AND ELEVATING IMMUNOLOGICAL FUNCTION IN LEWIS LUNG CANCER OF MICE[J];Journal of Anhui Traditional Chinese Medical College;2001-01
3 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
4 Sun Chengwen;Zhan Shu;Wei Yongdi;et al(The School of Basic Medical Sciences);Effects of astragalus saponins on Ca~(2+) -activated K~+channels of mouse T一lymphocytes[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1996-02
5 Lv Mingzhuang et al (The Affiliated Hospital of Guiyang Medical College);Experimental Research of Action of Aloe Extracts on Anti-free Radical Oxidation Damage DNA in Senile Model Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2003-03
6 wangjian, et al;Effection of blood vigor of SOD on mice treated by single ginseny and Ding Zhi Xiao wan[J];;1994-03
7 Chen Wansheng,Fan Wei,Yang Genjin,Qiao Chuanzhuo,Chen Haisheng,Yuan Yuan(Department of Pharmacognosy, College of Pharmacy,Second Military Medical University,Shanghai, 200433);Studies on the chemical constituents of Radix Polygoni multiflori Preparata[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-07
8 XU Zhi, WU Guo ming, QIAN Gui sheng, WANG Shi wen, XUE Qiao (Institute of Respiratory Diseases of PLA, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, China);Preliminary establishment of aging model in rat[J];Acta Academiae Medicinae Militaris Tertiae;2003-04
9 TAN Hua-bing(Medical Department,The People's Hospital of Yunyang Medical College,Shiyan 442000,China);Effect of Fiveleaf Gynostemma Herb on hyperlipoidemia and hemorheological changes in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;2007-15
10 DING Qiao ling,CHEN Pu yan (Key Laboratory of Animal Diseases Diagnostics and Immunology of Agriculture Ministry of P R of China, Nanjing Agricultural University , Nanjing,Jiangsu,210095,China);Pathogenesis of Marek's Disease (MD) and Mechanisms of Immunity Induced by MD Vaccine[J];Progress In Veterinary Medicine;2002-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 CHEN Xiao wen,FANG Zhao hui,CHENG Xiao yu (The First Affiliated Hospital,Anhui College of TCM,Anhui Hefei 230031,China);EFFECTS OF TANGKANGMING CAPSULE ON BLOOD GLUCOSE, BLOOD LIPIDS,HEMORRHEOLOGY IN DIABETIC RATS[J];Journal of Anhui Traditional Chinese Medical College;2001-05
2 LIN Ru 1,2 ,CAO Yu fang 2,HU Zheng hai 2* (1 College of Life Science,Fujian University of Agriculture and Forestry,Fuzhou 350002,China;2 Institute of Botany,Northwest University,Xian 710069,China);Anatomical structure of vegetative organs and histochemical localization of ginsenosides in Gynostemma pentaphyllum[J];Acta Botanica Boreali-occidentalia Sinica;2002-04
3 LIN Ru 1.2 , LIU Shi biao 1,CAO Yu fang 1,HU Zheng hai 1* (1 Institute of Botany, Northwest University, Xi'an 710069 China; 2 College of Life Science, Fujian University of Agriculture and Forestry, Fuzhou 350002 China);Studies on the correlation between the content of gypenosides and its vegetative organs and growth period[J];Acta Botanica Boreali-occidentalia Sinica;2003-07
4 He Ying;Wang Dongwu;Den Zhikuan(Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing,630038)Zhang Wei(Department of Statistics, Third Military Medical University,Chongqing,630038);Changes of intracellular calcium content and cerebral ultrastructures after brainstem ischemia in dogs[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1996-02
5 HOU Xiao-Ping; JIA Guo-Liang; ZhAOKuan; JIA Guang-Xing;; DA Ji-Ping(Department of Cardiovasology, Xijing Hospital,Fourth Military Medical University, Xi'an 710033)(General Hospital of Air Force,PLA);Effects of gypenosides on intimal proliferation and expression of c-sis oncogene in rabbit iliac artery afterballoon deendothelialization[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-05
6 HOU Hui-li~1,WANG Bao-li~1,GUO Yun-cheng~2,MAO Jianxiang~2,FU Tong-sheng~1(College of Animal Medicine,HNAU,Changsha,Hunan,410128,China;2.Taojiang Institute of Gynostemma Pentaphyllum,Yiyang,Hunan,413517,China);Effect of "Nanshen Xubao" on Activities of Serum Enzymes and Lactate Dehydrogenase Isozyme-Spectra in Finishing Pigs[J];Progress in Veterinary Medicine;2006-07
7 HOU Hui-li,FU Tong-sheng(College of Animal Medicine,Hunan Agricultural University,Changsha,Hunan,410128,China);Research Advance in the Chemical Ingredients and Pharmacological Effects of Gynostemma pentaphyllum[J];Progress in Veterinary Medicine;2006-S1
8 ZHANG Yu-song1,YANG Jiang-fan2,XIAO Gui-ping3,ZHANG Jing-xian4(1.Tea Processing Factory;2.College of Horticulture;3.College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China;4.Quanzhou Agricultural Bureau,Quanzhou,Fujian 362000,China);Extraction conditions for ginsenoside,flavone,polysaccharide in dry and fresh Gynastemma pentaphyllum and processing technique of the beverage[J];Journal of Fujian Agriculture and Forestry University(Natural Science Edition);2007-05
9 Yu Juan;Yang Shanzhang(Department of Pathophysiology,Fujian Medical College,Fuzhou,350004);Observation of Effects of Gynostemma Pentaphyllum on Platelet Disaggregation in Human[J];;1995-03
10 Rui Wen, Cen Yyingzhou, Xing Yingying, Su Miaoxian(Jinan university, Guangzhou 510632,China);Research on the Antihepatitis Herbal Medicine of Yao Nationality[J];Guangdong Chemical Industry;2005-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved