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《Chinese Journal of Pharmacology and Toxicology》 1991-02
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Combined pharmacokinetic and pharmacodynamic model for furosemide in rabbits

LIU Xiao-Quan, HUANG Sheng-Kai, LU Hong, YANG Jin-Yu Dept Pharmacology, China Pharmaceutical University, Nanjing 210009  
The pharmacokinetic and pharma codynamic profiles of furosemide were analyzed by the combined pharmacokinetic and pharmacodynamic model in rabbits. The pharmacodynamic parameters keo(the elimination rate constant of the effect compartment), S(Hill coefficient), EC50(the drug concentration at helf maximum effect), Emax(the maximum drug effect) for furosemide ((x|-)±SD) were 0.131±0.029 min-', 2.2±0.6, 3.5±μ0.8 μg/ml, and 6.5±0.6 ml/min, respectively. Following an iv dose offurosemide, its maximal diuretic effect occurred after the peak plasma concentration. This indicates that the plasma and effect site belong to different compartments and the equilibrium between the plasma and effect site does not reach instantaneously.
【Fund】: 江苏省科学技术委员会资助
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【Citations】
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