Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmacology and Toxicology》 1992-02
Add to Favorite Get Latest Update

Anti-lipid peroxidation and oxygen free radical scavenging activity of clausenamide

LIN Tong-Jun, LIU Geng-Tao, LI Xiao-Jie, ZHAO Bao-Lu, XIN Wen-Juan Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100080  
Clausenamide (Clau) is an alkaloid. The present investigation demonstrated that Clau inhibited ferrous-cysteine induced lipid peroxidation (malondialdehyde formation) of microsomes from the rat brain, heart, liver and testes. Electron spin resonance (ESR) detected that Clau scavenges oxygen radicals produced by human polymorphonuclear leukocytes (PML) stimulated by phorbol myristate acetate (PMA). However, no inhibitory effect of Clau on oxygen consumption of PML during respiratory burst was measured by spin label oximetry. In Fenton reaction system, 36.6% of OH was scavenged by Clau. It scavenged Oi by 21.2% and 16.2%, in xanthine-xanthine oxidase and UV-irradiation of riboflavin systems, respectively. It may be concluded that Clau exhibits an antioxidant activity via scavenging oxygen free radicals.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 6 Hits
1 CHENG Pei-feng,PAN Xue-diao,LI Nan,JIN Gui-fang,ZHAO Jin-huan,HU Feng,PAN Qin,ZANG Lin-quan(Department of Pharmacolgy,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China);Protective effects of clausenamide derivative on carbon tetrachloride and D-galactosamine induced acute liver injury in mice[J];Journal of Guangdong College of Pharmacy;2008-02
2 DAI Hong-fen1) LAI Zhi-yong2) LI Jian-guang1) HUANG Bing-xiong1) XIAO Wei-qiang1) WANG Xiao-rong1)(1)Institute of Pomology,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China;2)Puning Institute of Agricultural Sciences,Guangdong Province,Puning 515344,China);Determination of Chlorogenic Acid,Epicatechin and Rutin in Wampee and Wax Myrtle Flesh by HPLC[J];Journal of Huazhong Agricultural University(Natural Science Edition);2008-03
3 ZHANG Rui-ming1,2,WAN Shu-qing1*,ZHAO Dong-xiang2 1Key Labratory of Pesticide and Chemical Biology,Ministry of Education,South China Agricultural University,Guangzhou 510642,China;2Environment and Plant Protection Institute,CATAS,Danzhou,571737,China;Advances in Chemical Constituents and Biological Activities of Clausena lansium[J];Natural Product Research and Development;2012-01
4 Fen Yiying 1, Liu Binzhi 1, Wang Jucun 2 1?Department of Ophthalmology,Tianjin Nankai Hospital, Tianjin 300100,China;An effect of longdanxiegantang on oxygen free radicals and the lipid peroxidation induced by hydroxyl free radical[J];JOURNAL OF TRADITIONAL CHINESE OPHTHALMOLOGY;2000-02
5 WANG Ju-chun, XING Guo-sheng, HU Wen-duo, ZHU Tie-liang, WANG Qian, ZHAO Hua (Tianjin Hospital, Tianjin 300211 );Effects of Ge-132 on oxygen free radicals and the lipid peroxidation induced by hydroxyl free radical in vitro[J];Chinese Pharmaceutical Journal;1994-01
6 JIANG Zhu - chang , BI Gui-nan, SHI Sheng - liang. Department of Neurology, The Third Affiliated Hospital, Guangxi Traditional Chinese Medical University, Liuzhou 545001, Guangxi, China;Effect of clausenamide on the expression of Bcl - 2 protein and apoptosis after focal cerebral ischemia/reperfusion in renovascular hypertensive rats[J];Chinese Critical Care Medicine;2005-05
【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Ming-He, CAO Yan-Huai~* LI Wei-Xun~(**) YANG Yong-Qing, CHEN Yan-Yong and HUANG Liang (Institute of Materia Mediea, Chinese Academy of Medical Sciences, Beijing; ~* Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu;~(**) NO, 181 Hospital of PLA, Guilin);ISOLATION AND STRUCTURAL ELUCIDATION OF CLAUSENAMIDE FROM THE LEAVES OF CLAUSENA LANSIUM (LOUR.) SKEELS[J];Acta Pharmaceutica Sinica;1987-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Lin Hansen(Guangdong College of Pharmacy,Guangzhou,P.R.China 510224);Resolution of Neoclausenamidone[J];ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY;1999-02
2 PAN Xiao-ping, LI Mei-ru, YANG Qian~* ( South China Institute of Botany, The Chinese Academy of Sciences, Guangzhou 510650, China );Callus induction and respond to different phytohormone of Clausena lansium[J];Guihaia;2004-02
3 周俊 谭宁华(中国科学院昆明植物研究所 植物化学开放研究实验室 昆明 650204);中国植物化学的回顾与展望[J];Chemistry;1999-12
4 Yang Ming-He Chen Yan-Yong Huang Liang~*(Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing);Studies on the Chemical Constituents of Clausena Lansium(lour.) Skeels II. The Isolation and Structural Elucidation of Neoclausenamide and Cycloclausenamide[J];Acta Chimica Sinica;1987-12
5 Lin Hansen (Department of Pharmacy, Guangdong College of Pharmacy Guangzhou 510224);THE SYSTHESIS OF 3 HYDROXY 4 PHENYL 5 BENZOYL N METHYL γ LACTAM[J];WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES;1999-04
6 Dai Bing et al Guangxi Institute of National Medical Research;Pharmacognostic studies on Leaves of Clauseua Lansium[J];Chinese Journal of Ethnomedicine and Ethnopharmacy;1997-06
7 SHEN Wen-wei1,2,LI Wen1,2,3,WANG Guo-cai1,2,WU Xia1,2,YE Wen-cai1,2,LI Yao-lan1,2(1.Institute of Traditional Chinese Medicine & Natural Products,College of Pharmacy; 2.Guangdong Province Key Laboratory of Pharmaceutical Constituents of TCM and New Drugs Research,Jinan University,Guangzhou 510632,China; 3.Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,China);Chemical constituents of Clausena lansium[J];Journal of Jinan University(Natural Science & Medicine Edition);2012-05
8 Huang Xuesong et al;Determination of the clausenaminede in the fruit and seed of Clausena lansium(Lour.) Skeels[J];Science and Technology of Food Industry;2006-06
9 ZHANG Rui-ming1,2,WAN Shu-qing1*,ZHAO Dong-xiang2 1Key Labratory of Pesticide and Chemical Biology,Ministry of Education,South China Agricultural University,Guangzhou 510642,China;2Environment and Plant Protection Institute,CATAS,Danzhou,571737,China;Advances in Chemical Constituents and Biological Activities of Clausena lansium[J];Natural Product Research and Development;2012-01
10 YAO Qing Qiang, WANG Mu Zou (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050);Stereoselectivity of chiral clausenamide biotransformation[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;1999-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yin Xuejun, Liu Dexiang Laboratory of Medical Genetics, Urumchi General Hospital, Lanzhou Command, Urumchi, Xinjiang;STUDY ON THE MUTAGENiCITY OF EXTRACTS FROM 102 CHINESE HERBS[J];Carcinogenesis,Teratogenesis and Mutagenesis;1989-00
2 Nie Yuxiu, Zhang Shugong Chen Yulan, Ni Jiazan, Zhao Peilin (Department of Histology and Embryoloy);OBSERVATION OF THE EFFECT OF Ge-132 ON HUMAN DIPLOID CELLS IN VITRO[J];;1990-02
3 WEN Ke 1, CHEN Jin 2, LI Hong 1 ,DAI Wen wan 3, LI Jin xuan △, YANG Shi jie 1 (1. Dept.of Pharmacology, School of Basic Medical Sciences,Jilin University, Changchun 130021, China; 2. Dept. of Pharmaceutics,People Hospital, Beihai,Guangxi; 3.;Comparision of antitumor activity among four antitumor drugs including Phellinus linteus[J];Journal of Norman Bethune University of Medical Science;2002-03
4 Li Ningning 1,Xin Xiaolin 2,Sun Hongzhao 2 (1 Teachers College of Qindao University,Qingdao 266071,Shandong,China; 2 Yantai Teachers College,Yantai 264025,Shandong,China);EFFECT OF AGROCYBE CHAXINGU POLYSACCHARIDE ON ISOLATED SKELETAL MUSCULAR FATIGUE[J];Journal of Binzhou Medical College;2004-01
5 NIU Jian-yi*, CHEN Hong-bing. *Department of Neurology, Yidu Central Hospital of Weifang City, Weifang 262500, China;Research progress of cerebral ischemia and COX-2[J];Chinese Journal of Neuromedicine;2005-02
6 Wan Xiaoxing, Zhou Guangqi, Wang Peizhong, Wang Shilong (Dept. of Food Sci. and Bio tech. Eng., Dalian Inst. of light Ind., Dalian, China, 116001) Bai Changchuan (Traditional Chinese Hospital of Dalian, Dalian, China, 116013);Effect of Herbs on Deep Fermentation of Cordyceps Militars[J];JOURNAL OF DALIAN INSTITUTE OF LIGHT INOUSTRY;1998-04
7 Zou Yaohong (Department of Chemistry, Changshu College, Changshu 215500) Li Guirong (Dongcheng Company of Domestic Chemistry, Zengcheng 511370);Analysis of Flavonoid as Antioxidant in Myrica Rubra Leaf With Reversed-phase High Performance Liquid Chromatography[J];Chinese Journal of Analytieal Chemistry;1998-05
8 LU Hai-bo,WAN Shu-qing (Key Lab.of Pesticide and Chemical Biology,Ministry of Education/Laboratory of Insect Toxicology,South China Agricultural University,Guangzhou 510642 China);Study on allelopathy activity of the methanol extract from Clausena lansium[J];Guangdong Agricultural Science;2005-04
9 Kong Xiaolong,Jiang Weizhe,Lin Zizhong.(Department of Pharmacy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021 China);THE AFFECTION OF CLAUSENAMIDE TO LEARNING AND MEMORY DYSFUNCTION OF RATS INDUCED BY β-AMYLOID PEPTIDE FRAGMENT 25~35[J];Journal of Guangxi Medical University;2003-05
10 Zhang Yuanzhen, Wang Yan, Cao Yulan, et al Department of Obstetrics and Gynecology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;The Change of MDA,SOD and Vitamine E in Umbillcal Blood and Patients with Pregnancy Induced Hypertension[J];Journal of Hubei Medical University;2003-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Sheng-ming (Department of Chemistry,Qinghai Nationalities University,Xining,Qinghai 810007);Study on the Extraction of Polysaccharide from Rhodiola crenulata by Alkali Method and Its Antioxidation[J];Journal of Anhui Agricultural Sciences;2008-18
2 GE Qun-mei et al(Institute of Resource Microorganism,Huaiyin Teacher's College,Huaian,Jiangsu 22330);Study on the Content Determination of Polyphenol in Water Extracts from Humulus scanalens (Lour) Merr.and Its Antioxidant Activity[J];Journal of Anhui Agricultural Sciences;2009-09
3 CAO Peng-fei(Lishui Agricul Ture Science,Lishui,Zhejiang 323000);Study on Antioxidation of Tannin from Pomegranate Rind and Green Tea[J];Journal of Anhui Agricultural Sciences;2011-20
4 Liu Yuling , Chen Xiaying , Chen XuLin, et al.Department of Experimental Surgery Laboratory of the First Clinical College in Anhui Medical University , Hefei , 230032;Effect of salvia miltiorrhizae on water content in rats during early postburn stage[J];;2006-03
5 FANG Wei1,CHEN Yan1,SUN Yu-jun1,2(1.School of Life Science,Anhui University,The key lab of Chinese traditional medicine research and development of Anhui Province,Hefei 230039,China;2.School of Life Science,Anhui Science and Technology University,Fengyang 233100,China);Protective Effect of Tea Polysaccharides on Carbon Tetrachloride Induced Liver Injury in Mice[J];Journal of Tea Science;2008-01
6 ZHU Xiong Xiang, TANG Chao Wu, CHEN Bi Department of Burn Surgery, Center of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Effect of burn patient's serum and Salvia miltiorrhiza on chemiluminescence magnitude of normal blood polymorphonuclear neutrophils[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-10
7 WANG Jun dong,LI Shu qin,SHEN Rui ling,WANG Jian ling (College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu,030801,China);Effects of Four kinds of Chinese Medicinal Recipes on Part Characteristic in Broiler[J];Progress In Veterinary Medicine;2002-04
8 LAI Pu-fu,LI Yi-bin,CHEN Jun-chen,ZHOU Xue-hua,SHEN Heng-sheng(Research Institute of Agri-Engineering Technology,Fujian Academy of Agricultural Sciences/Agricultural Product Processing Research Centre,Fujian Academy of Agricultural Sciences,Fuzhou, Fujian 350003,china);Studying Storage Stability of Spray Drying Powder from Blanching Water of Stropharia rugoso-annulata[J];Fujian Journal of Agricultural Sciences;2012-03
9 SHEN Qi-ying 1, SHEN Qiu-ying 2 ( 1 Petroleum Chemical Industry College in Beijing, Beijing 102600, China; 2 Petroleum College in Fushun, Fushun 113001, China );Study on the resisting oxygen free radical and hydroxyl free radical effect of Cordyceps militaris[J];Guihaia;2001-03
10 LIU Hong 1,2 , GUO Si yuan 1, HAN Chang ri 2, JI Ming hui 2, LI Lin 1 ( 1 College of Light Industry and Food, South China University of Technology , Guangzhou 510641, China; 2 Department of Chemistry, Hainan Normal University , Haikou 571158, China );Separation of the antioxidative ingredient from Alpinia oxyphylla Miquel[J];Guihaia;2005-05
China Proceedings of conference Full-text Database 2 Hits
1 JiaoShirong HuangChengyu SongWeiwei (School of public health, Sichuan university, Chengdu 610041, China; School of Bioengineenng of Xlhua University, Chengdu 610039, China );Study on the Antioxidant Activity of Citrus Aurantium Extract in Vitro[A];[C];2006
2 GAI Yu-hong~1,SONG Hui~1,WEI Jian~2 (1.College of Agronomy,Jilin Agricultural University,Changchun 130118,China;2.School of Life Science, Changchun Normal College,Changchun 130064,China);Research on Antioxygen Activity of Ganoderma lucidum Liquid Submerged Fermentation Polysaccharides[A];[C];2007
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved