Influence of hebane drugs on cerebral and myocardial blood flow and cardie index in rats
ZHANG Ying-Ge, KE JunDepartment of Pharmacology, Henan Medical University, Zhengzhou 450052
With chromium radioisotopes (51Cr) using the radioactive biomicrosphere assay labeling frog erythrocytes, the influence of hebane drugs (HD) on the cerebral blood flow (CBF), myocardial blood flow (MBF) and cardiac index (CI) of rats was studied. The results demonstrated that HD increased CBF and MBF but decreased CI. Anisodamine 10-40 mg·kg-1 iv increased CBF of the hemisphere by 26-73%; scopolamine 1.25-5 mg·kg-1, by 17-38%; and atropine 2.5-10 mg·kg-1, by 17-64%. Anisodamine also increased MBF but the effect reduced when the dose was larger than 20 mg·kg-1. Indeed, anisodamine 10-20 mg ·kg-1 iv increased MBF by 128-198% but 40 mg·kg-1 iv only gaves a 62% increment. Scopolamine 1.25-5·kg-1 iv increasedMBF by 51-116% and atropine 5-10 mg·kg-1 iv by 113-137%. The three drugs at various doses used in this experiment decreased CI significantly but scopolamine 5 mg·kg-1 iv decreased CI insignificantly. These results indicated that HD could change the distribution of the blood flow to ensure the blood supply for the brain and heart. This might explain why HD could be used effectively in the treatment of shock.