Effects of atropine, scopolamine and anisodamine on the proliferation of rabbit aortic smooth muscle cell
ZHANG Ming-Zhi, CHEN Jing-Ming, ZHONG Yan-Yan, ZHANG Guang-Yi Department of Cell Regulation, Xuzhou Medical College, Xuzhou 221002
The effects of atropine, scopolamine and anisodamine on the proliferation of the cultured rabbit aortic smooth muscle cells (ASMC) were studied. In the normal culture medium (Ca2+-present), all the three drugs inhibited the ASMC proliferation. In the Ca2+-free culture medium, all the three drugs hadbiphasic effects on ASMC proliferation, stimulatory at low concentrations and inhibitory at high concentrations.