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《Chinese Journal of Pharmacology and Toxicology》 1992-04
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Effects of gypenosides on splenocyte proliferation and relationships with hypothalamic and splenic norepinephrine and plasma corticosterone in rats

ZHANG Yong-Xiang, ZHOU Jin-Huang, XING Shan-Tian,YUAN Shu-Lan. RUAN Jin-Xiu Institute of Pharmacology and Toxicology, Beijing 100850  
The immunopotentiating effects of gypenosides (GPS) in relation to the network of neuroendocrine-immune modulation (NIM) were examined. It was found that daily injection of GPS in rats for 7 d produced a significant increase in Con A stimulated splenocyte proliferation with a marked decrease of norepinephrine (NE) in the hypothalamus and spleen detected by high performance liquid chromatography (HPLC); the plasma level of corticosterone (CS) was also decreased (detected by ra-dio-immunoassay). These results indicate a close relationship between the neuroendocrine activities and the immunofunctions, and suggest that the mechanism of immunomodulating effects of GPS may be mediated through NIM network.
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