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《Chinese Journal of Pharmacology and Toxicology》 1993-03
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Scavenging effect of anisodamine on superoxide anion radical and its protection on sulfhydryl group in erythrocyte membranes of rats in vitro

CAO Zhao-Feng,WANG Qiu-Ju,LUO Ling,FU Ding-Yi(Laboratory of Immunopathology and Cytotoxicology,Department of Pharmacology,North China Coal Medical College,Tangshan 063000)  
The scavenging effect of anisodamine(Ani)on superoxide anion radical(O2-)was investigated in vitro in chemiluminescence experiments.Ani(1-4 mg·ml-1)could remarkably scavenge O2-in hypoxathine/xanthine oxidase(HX-XO)system.Incubation of rat erythrocyte membranes with H2O2 resulted in a loss of SH groups.An addition ofAni(l-2 mg·ml-1)into the incubation mixture effectively reduced the loss of SH groups.The results further suggest that Ani has an antioxidation activity.
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