Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmacology and Toxicology》 2001-01
Add to Favorite Get Latest Update

Effect of salvianolate on renal function and endogenous endothelin release in chronic renal failure rats

XU Man, WANG Yi Ping, SUN Wei Kang, XUAN Li Jiang, XU Ya Ming (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China)  
The effects of salvianolate on renal function and endogenous endothelin release were studied in a rat model of adenine induced chronic renal failure(CRF). CRF rats were administrated ip for 14 d with normal saline in control, salvianolate 5, 10, 15 mg·kg -1 in treated animal, respectively. The renal function was improved dose dependently by salvianolate in decreasing both serum creatinine and urea nitrogen. Besides, the plasma endothelin, calcium content of renal cortex, the mean glomerular volume(GV), the basement membrane thickness, and the mean tubular area(TA) in salvianolate group were compared with that of CRF animal. The results showed that plasma endothelin and calcium content of renal cortex were reduced, the increase in GV, the rise of the basement membrane thickness, the decreased of TA were also inhibited by salvianolate. The results indicate that salvianolate improve the renal function and prevent the development of renal failure, which may be related to the inhibition of endogenous endothelin release.
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 Gui Zehong,Dai Ruixin,Deng Shigui,et al Second Clinical Medical College,Guangzhou TCM University(510120);Salvia Injection’s Effect on Obstructive Nephropathy Rats’ Kidney Function and TGF-β_1 Expression[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-03
2 Li Junxia, Jiang Yunsheng Department of Nephrology, Fuzhou General Hospital, Fuzhou 350025.;THE CLEARANCE OF MIDDLE MOLECULAR SUBSTANCE BY GRASTROINTETINAL TRACT[J];Journal of Fuzhou Genenal Hospital;2005-02
3 Hu Ying,Zha Yan,Yan Xiaoyong.Departmentment of Nephrology,The People's Hospital of Guizhou Province,Guiyang 550001,China.Departmentment of Nephrology,The Affiliated Hospital of Zunyi Medical College Zunyi 563003,Chian;Effect of salvianolate injection on plasma endothelin-1 and calcitonin gene related peptide levels in treating chronic renal failure[J];Guizhou Medical Journal;2011-06
4 ZHANG Xiao-lei1,CHEN Jun-hua1,GUO Chun-xia2,XIN Xian-liang1 (1.Shanghai Green Valley Pharmaceutical Co.,Ltd.,Shanghai 201203;2.Shanghai University of TCM,Shanghai 201203,China);Research progress on pharmacological activities of salvianolate[J];World Clinical Drugs;2013-05
5 CAO Lei,LUO Hong.(Department of Nephrology of Bengbu Third People's Hospital,Anhui 233000,China);Clinical research of treatment of chronic renal failure with low-dose dopamine combined with alprostadil[J];Journal of Huaihai Medicine;2012-01
6 Liu Zhi-jun,Hao Jian,Wu Sheng,Li Shu-wen,Qian Jun,Lv Lai-di,Yan An(The Hospital Directly under the Hangzhou Sanitarium of Nanjing Command,PLA,Hangzhou Zhejiang 310007,China);Protective effect of treatment of salvia miltiorrhiza polyphenols injection for pulmonary vascular endothelial function in patients with COPD and hyoxemia[J];Clinical Journal of Medical Officers;2012-04
7 ZHA Fangfang ZHU Yingchun WU Lianye WANG Qing DU Hongxiu BAI Shoujun Department of Nephrology,Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai 201700,China;Preventive Effects of Salvianolate Combined with Alprostadil and Glutathione on Progression of Renal Failure in Patients with Diabetic Nephropathy[J];Chinese Journal of Clinical Medicine;2013-03
8 FUXu;LI Jun;Department of Traditional Chinese Medicine,Fifth Affiliated Hospital of Zunyi Medical College;;Research progress of water-soluble component of Salvia miltiorrhiza in chronic kidney disease[J];Global Traditional Chinese Medicine;2013-09
9 YANG Lin-lin,JI Xiang-wu,ZHANG Ai-yuan,et al.Weifang Medical College,Shandong,Weifang 261042,China;The clinical observation of salvianolate in patients with unstable angina[J];Chinese Journal of Clinical Rational Drug Use;2010-02
10 SHAO Ming-hai WANG Chen YANG Jing HE Li-qun Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; The Key Laboratory of Liver and Kidney Diseases of Ministry of Education,Shanghai;Effects of Salvianolate on Renal Function and Renal Oxygen Consumption in Rats with Chronic Renal Failure[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2012-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIANG Yong-feng(College of Chemistry and Chemical Engineering,Ningxia Normal University,Guyuan,Ningxia 756000);Comparative Study on Chemical Constituents from Rheum palmatum L.and Rheum hotaoense C.Y.Cheng et C.T.Kao[J];Journal of Anhui Agricultural Sciences;2009-26
2 ZHANG Jing(The People's Hospital of Fuyang,Anhui 236000);Clinical value about chronic renal failure with shenfu soup therapy[J];Anhui Medical and Pharmaceutical Journal;2005-11
3 XU Yong1;ZHAO Cheng2(1.Luan Hospital of Traditional Chinese Medicine;2.Luan Institute for Drug Control,Luan 237000,China);Effects of different extractive methods on the content determination of salviandic acid B in salvia militorrhiza bge.[J];Anhui Medical and Pharmaceutical Journal;2009-10
4 Li Feng,Zhang Xiaoming,Zhang Yun,Ye Chuanhui,Cheng Qingli (Department of TCM,Xijing Hospital,Fourth Military Medicial University,PLA,Xi’an 710032,China);EFFECT OF SHENKANG INJECTION ON LEVEL OF ET 1 AND NO SECRETION IN CULTURED GLOMERULAR MESANGIAL CELL[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-02
5 MA Jian-wei,CAI Qing,LIU Zhan-min,XU Li-mei, CHEN Bao,WEI Han-lin,HOU Jie,DONG Jing (General Hospital of Air force,PLA,Beijing 100036,China);EFFECT OF ZISHEN HUOXUE JIEDU RECIPE ON mRNA EXPRESSION OF ET-1 IN REMNANT KIDNEY OF RATS WITH CHRONIC RENAL FAILURE[J];Journal of Anhui Traditional Chinese Medical College;2001-01
6 LIN Ji-xiang (Shanghai Seventh People′s Hospital, Shanghai 200137,China);Effect of Cordyceps on Mesangial Cell Proliferation[J];Journal of Anhui Traditional Chinese Medical College;2003-04
7 GAO Hui,LI Xian-hui,LI Chun-yan,L Jiang-ming(Department of Pharmacology,Medical College of Jishou University,Jishou 416000,China);Effect of salvianolate on the platelet aggregation and adhesiveness in healthy volunteers[J];Journal of Bengbu Medical College;2007-05
8 Yu Dongrong (Hangzhou Hospital of TCM, Hangzhou 310006);Clinical Analysis on 100 Cases of Glomerulonephritis Treated with Bai Ling Capsule[J];Journal of Zhejiang College of Tcm;1996-04
9 Li Hui,Chai Kefu,Lou Jiwei △ Zhejiang College of TCM,Hangzhou(310053)△Shanghai Meitong Biological Sci tech Co.Ltd.;Experimental Studies of Treating Chronic Renal Failure with Yishen Huoxue Fang[J];Journal of Zhejiang College of Tcm;2000-06
10 Wang Yongjun National TCM Nephrosis Treatment Center,Hangzhou Municipal Hospital of Traditional Chinese Medicine(310007);Experience of Treating Chronic Renal Failure[J];Journal of Zhejiang College of Tcm;2003-02
China Proceedings of conference Full-text Database 1 Hits
1 JIANG Qijun LIANG Chun HE Zhiqin WU Jianxiang TAN Hongbin SUN Chengbo PAN Xiaoming WU Zonggui Department of Cardiology,Changzheng Hospital,Second Military Medical University,Shanghai(200003);Salvianolate inhibit proliferation and migration of endothelial progenitor cells via Akt/eNOS pathway[A];[C];2008
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LIU Cai-hong1,HE Yong1,Lü Ling2(1.Chizhou People's Hospital,Chizhou 247000;2.Anhui University of Traditional Chinese Medicine,Hefei 230038);Determination of dan phenolic acid B in yindanxinnaotong capsules by HPLC[J];Anhui Medical and Pharmaceutical Journal;2008-11
2 DIN Jiao-sheng The Second People's Hospital of Jiaozuo City,Jiaozuo 454000,China;Comparative study of effects of Danshen injection and Alprostadil injection on off-body perfused kidney[J];Acta Medicinae Sinica;2011-03
3 WANG Jin-ju1),DAI Da-shun2).1) Zhengzhou People's Hospital,Zhengzhou 450003,China;2) Henan Provincial Hospital of Traditional Chinese Medicine;Efficacy of salvianolate in the treatment of patients with unstable angina pectoris and its effect on serum matrix metalloproteinases-2[J];Clinical Medicine;2013-01
4 Chen Kai (Kaifeng Second People's Hospital Department of Nephrology, Kaifeng 475000);Clinical Research of Combined Traditional Chinese and Western medicine methods in Treatment with Diabetic Nephropathy[J];Guangming Journal of Chinese Medicine;2013-04
5 ZHANG Xiao-lei1,CHEN Jun-hua1,GUO Chun-xia2,XIN Xian-liang1 (1.Shanghai Green Valley Pharmaceutical Co.,Ltd.,Shanghai 201203;2.Shanghai University of TCM,Shanghai 201203,China);Research progress on pharmacological activities of salvianolate[J];World Clinical Drugs;2013-05
6 WANG Xiao-xing;TU Yuan-bao;LIU Xian-liang;LI Chuan-ping;ZHANG Xiao-min;Department of Nephrology,Lu'an Hospital of Traditional Chinese Medicine;;Clinical Efficacy of Yin-Nourishing and Blood-Activating Prescription in IgA Nephropathy Patients with Yin-Deficiency and Blood-Stasis Syndrome:A Report of 60 Cases[J];Journal of Anhui University of Chinese Medicine;2014-04
7 Zhang Yong;Department of Cardiovascular Diseases, the Third People's Hospital of Yibin;;Effects of Salvianolate on Serum High Sensitivity C-reactive Protein and Tumor Necrosis Factor-α of Acute Coronary Syndrome Patients[J];World Notes on Antibiotics;2014-05
8 QU Kai;Department of Nephrology, Shaanxi Hospital of Chinese Medicine;;Establish diagnostic criteria of chronic renal failure based on syndrome factors and combination of disease and syndrome[J];China Journal of Traditional Chinese Medicine and Pharmacy;2014-11
9 XU Tai-jing;LI Jian-jun;DING Yi;Internal Medicine Department of Nephrology of Huishan District People's Hospital;;Clinical Study on Efficacy of Integrated Traditional Chinese and Western Medicine on Chronic Glomerular nephritis[J];Journal of Chengdu University of Traditional Chinese Medicine;2014-04
10 Luo Min;Li Xiangrong;Department of Cardiology,Fifth People′s Hospital of Nanchong City;;Curative effect analysis of salvia miltiorrhiza salt in the treatment of angina pectoris after thrombolysis of acute ST-elevation myocardial infarction[J];Chongqing Medicine;2015-32
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved