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《Chinese Journal of Pharmacology and Toxicology》 2002-03
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Effects of thiopental sodium on ATPase activities in different brain regions of rats

ZHANG Lin 1, DAI Ti Jun 2, LIU Hong Liang 1, MENG Jing 2, DUAN Shi Ming 2 (1. Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China, 2. Key Lab of Anesthesiology of Jiangsu Province, Affiliated Hospital  
AIM To investigate whether the dynamic changes of ATPase activities induced by thiopental sodium are related to its anesthetic effect. METHODS Forty SD rats were randomly divided into five groups(control, induction, anesthesia, restoration, awake). Thiopental sodium (30 mg·kg -1 , ip) or normal saline (10 mL·kg -1 , control group) was intraperitoneally injected respectively. The activities of Na +,K + ATPase and Ca 2+ ATPase were measured by spectrophotometric analysis. RESULTS Thio pental sodium treatment decreased the Na +,K + ATPase activity of cortex in rats significantly in phases of induction and restoration, while Ca 2+ ATPase activity of cortex was increased significantly in phases of induction and anesthesia, and the two ATPases restore to the level of control in awake phase. After administration of thiopental sodium, Na +,K + ATPase and Ca 2+ ATPase activities of brain stem were significantly lower than those in control group, even in awake phase. The activities of ATPases of hippocampus and striatum were changed little. CONCLUSION The central inhibitory effects of thiopental sodium may be related to the changes of the activities of Na +,K + ATPase and Ca 2+ ATPase in cortex and brain stem of rats.
【Fund】: 国家自然科学基金资助项目 (39970 715 )~~
【CateGory Index】: R965
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