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《Chinese Journal of Pharmacology and Toxicology》 2008-04
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Effect of Cistanche tubulosa (Scheuk) Whight acteoside on telomerase activity and immunity of aging mice

ZHANG Hong-Quan,WENG Xiao-Jing,CHEN Li-Li,LI Xin(Medical and Pharmaceutical Institute,Yangzhou University,Yangzhou 225001,China)  
AIM To study the effect of Cistanche tubulosa (Scheuk) Whight acteoside(CTWA) on malondialdehyde(MDA) content,telomerase activity in heart,liver and brain tissues and immune function of experimentally aging model mice.METHODSMice were given sc 10% D-galactose 10 mL·kg-1,once daily for 8 weeks to establish model of aging mice.CTWA 10,20 and 40 mg·kg-1 were given ig,respectively,from the ninth week once daily for 2 weeks.The MDA content and telomerase activity were measured with thiobarbituric acid colorimetric method and PCR-ELISA,respectively.The lymphocyte proliferation was measured by TdR incorporation test.Phagocytosis of peritoneal macrophages was tested by neutral red test.The interleukin-2(IL-2) content in peripheral blood was measured by radioimmunoassay.RESULTS In model group,MDA content was significantly increased in heart,liver and brain,telomerase activity was significantly decreased in heart and liver,and lymphocyte proliferation,phagocytosis of peritoneal macrophages and blood IL-2 content were obviously decreased. After treatment with CTWA for 2 weeks,MDA content in heart,liver and brain was significantly decreased.In CTWA 40 mg·kg-1 group telomerase activity in heart and brain was significantly increased,lymphocyte proliferation,phagocytosis of peritoneal macrophages and peripheral blood IL-2 content obviously enhanced.CONCLUSION CTWA may delay aging,which may be related to antagonizing free radical injury and enhancing immunity of aging mice.
【CateGory Index】: R285.5
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