Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmacology and Toxicology》 2011-06
Add to Favorite Get Latest Update

Genetic toxicity of Bristletoothoak extract

LU Miao-gui1,JIANG Qiao-ling2,CAI De-lei3,ZHEN Yun-yan3 (1.Institute of Communicable Diseases Control,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;2.Department of Blood-Donation Service,Zhejiang Provincial Blood Center,Hangzhou 310006,China;3.Institute of Hygiene Toxicology,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China)  
OBJECTIVE To evaluate the genotoxicity of bristletoothoak extract.METHODSMicronucleus assay,karyotypes test,bacterial mutation assay(Ames test) and HGPRT forward mutation assay in V79 cell line,with presence or in absence of S9,were performed to determine the mutagenicity of bristletoothoak extract.Bristletoothoak extract 6.25,12.5,25,50 and 100 mg groups were set in Ames test,and number of reversional mutation colony was counted directly in culture medium.Bristletoothoak extract 2.5,5.0 and 10 g·L-1 groups were set in HGPRT forward mutation assay in V79 cell line,and colony was directly counted,and mutation frequency(MF) was calculated.Bristletoothoak extract 2.5,5.0 and 10.0 g·kg-1 groups were set,in micronucleus assay and karyotypes test and 1000 polychromatic erythrocytes(PCE),1000 complete sperms per animal were observed by microscopy,and PCE count with micronuclei count and type of malformed sperms were recorded,and micronuclei rate and sperm malformation rate was calculated.RESULTSBristletoothoak extract 100 mg per dish with or without S9,and the number of reversional mutation colony in Bristletoothoak extract groups was not higher than 2 times of that in solvent control group in Ames test,and MF in 3 Bristletoothoak extract groups was not satisfied with positive criteria,above 3 times of that in normal control group in mutation assay in V79 cell line.Ames test and gene mutation results in V79 cells showed negative.Compared with control group,micronuclei rate and sperm malformation rate had no significant difference among Bristletoothoak extract 2.5,5.0 and 10 g·kg-1 groups.CONCLUSION Bristletoothoak extract does not cause any measurable genotoxicity.
【CateGory Index】: R285.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Wang Xinsheng;The Determination of Mutagenicities of Cosmetics by Tradescantia Micronucleus Technique[J];Journal of Environment and Health;1992-01
2 CHEN Xinmei,ZHANG Huiru,WU Jicheng,ZHU Guangyu(Research Institute of Forest Resource Information Techniques,Chinese Academy of Forestry,Beijing 100091,China);Study on Diameter Distribution Simulation of Quercus mongolica Stands[J];Forest Resources Management;2008-01
3 Yang Fangju Zhou Lioning Hong Zheng Feng Ziping(Depactment of Phanmacology, West China Vmiversity of Medical Seiences, CHengdu 610044);STUDY ON THE GENE MUTATION OF MAMMAL CELLS V79 CULTURED BY HOME-MADE SPARFLOXACIN[J];Sichuan Journal of Physiological Sciences;1997-03
4 Yang Chun-mei1,2,Ai Hong-jun1,Zhang Yue21Stomatology Medical College,China Medical University,Shenyang 121000,Liaoning Province,China; 2School Hospital of Liaodong College,Dandong 118003,Liaoning Province,China;Salmonella typhimurium Ames test for poly-beta-hydroxybutyrate[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-21
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Shu-min et al (Life Science College,Langfang Teachers College,Langfang,Hebei 065000);Study on Genotoxicity of Shampoo Concentrations to Root Tip Cell of Vicia faba[J];Journal of Anhui Agricultural Sciences;2009-24
2 HU Bao-gang et al (Forestry Bureau of Central District,Zaozhuang,Shandong 277110);Simulation Study on Diameter Structure of Populus nigra Stand in Zaozhuang City[J];Journal of Anhui Agricultural Sciences;2010-23
3 TANG Wei LU Kanghong (Sichuan Province Yuechi Normal School, Yuechi, 638300 China Suining Education and Science Research Institute, Suining 629000, Chian);Studies on Pollution of Parathion-methyl by Experiment[J];Journal of Northern Sichuan Education College;2003-02
4 Zhu Liang,Sun Wenpeng. (College of Environmental Science and Engineering,Hohai University,Nanjing Jiangsu 210098);Safety assessment for surface waters using the Comet assay[J];Environmental Pollution & Control;2007-04
5 Second Military Medical University(Shanghai,200433) Q. Y. Chi,C. L. Xu,Q. Y. Sun ,B. J. Chen ,Y. L.Li;Tradescantia-Micronucleu Test for Mutation of Disinfectant[J];Journal of Environment and Health;1993-06
6 ZHANG Jiang-li,WANG Shu-min,GAO Yong-chuang,et al. Langfang Teachers College,Life Science College,Langfang,Hebei 065000,China;Genetic Toxicity of Shampoo to Root Tip Cells of Vicia faba[J];Journal of Environment and Health;2009-09
7 Tang Qingguo,Chen Xiaochun Yunnan Provincial Sanitaion and Anti epidemic Station,Kunming 650022;The Detection of Mutagenicities of Cosmetics by Root Tip Cells of Vicia Faba Micronucleus Technique[J];JOURNAL OF ENVIRONMENT AND HEALTH;1997-05
8 XIANG Yangzhou,XU Daping,YANG Zengjiang,ZHANG Ningnan,GUO Junyu(Research Institute of Tropical Forestry,CAF,Guangzhou 510520,China);The Model of Diameter Distribution for Eucalyptus Plantations in Hainan Province[J];Forest Resources Management;2011-03
9 Hu Mingchen1,2,Ren Fazheng2,Luo Hongxia3,Wang Fang3,Qiu Fangping1+(1 School of Chemistry and Life Science of ChangChun University of Technology,Changchun 130012 China;2 College of Food Science and Nutritional Engineering of China Agricltural University,Beijing 100083,China;3 Scool of Food and Biological Engineering of Beijing Agricltural Vocational University,Beijing 102442,China);Progress of genetic toxicity test[J];Journal of Food Safety & Quality;2011-02
10 MU Xiao-qun,MA Ling,TAN Zhuang-sheng(Beijing Municipal Center for Disease Prevention and Control,Beijing 100013,China);DNA damage by chlorinated disinfection during water reuse in the lymphocytes from the spleen of mice assessed by the comet assay[J];Journal of Toxicology;2009-04
China Proceedings of conference Full-text Database 1 Hits
1 ;饮用水源遗传毒性可利用技术研究概述[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YU Shun li, MA Ke ping, CHEN Ling zhi ( Institute of Botany, the Chinese Academy of Sciences , Beijing 100093, China );Preliminary discussion on the origin of Quercus mongolica forest in north China[J];GUIHAIA;2000-02
2 Lu Hua, Sun Jiao (Shanghai Biomaterials Research and Test Center. School of Stomatology, Shanghai Second Medical University. 200023 Shanghai);Study on the Ni-Cr casting alloy used for porcelain by Ames test[J];Chinese Journal of Dental Materials and Devices;2003-02
3 Ли Ко-з (Сезеро-зосточный лесотехнический институт);ИЗУЧЕНИЕ ПОРОСЛЕВОЙ ДУБРАГЫ[J];Scientia Silvae Sinicae;1958-03
4 Tang Suyang,Ai Yufeng,Dong Zhaolin,et al Chinese PLA 205 Hospital (Jingzhou 121000);THE EVALUATION AT THE CYTOTOXITY OF POLY-β-HYDROXYBUTYRATE AT THE FIBROBLASTS OF MICE IN VITRO[J];CHINESE JOURNAL OF AESTHETIC MEDICINE;2000-02
5 AI Wei-bing, AI Yu-feng, XIONG Meng, TIAN Jin-hong, YI Cheng-gangWU Jin-hua, ZHANG Lin-xi, YANG Qing-fang, DONG Zhao-lin (Department of Plastic Surgery, Xijing Hospital,the Fourth Military Medical UniversityXi′an 710032, Shaanxi Province, China);Experimental studies on a neotype polyhydroxybutyrate as scaffold for vascular tissue engineering[J];Chinese Journal of Aesthetic Medicine;2005-02
6 WU Jin-hua1 ,AI Yu-feng1, LIU Li-ping2 ,AI Wei-bing1,YANG Qing-fang3,DONG Zhao-lin4 (1.Plastic Surgical Center of XiJing Hospital The Fourth Military Medical University, Xi'an 710032,Shaanxi Province,China;2.The Fourth Hospital of Xi'an;3.Northwesten Polythenical University;4.Northwesten University);Experimental studies on the complex of cytocompatibility of polyhydroxybutyrate(PHB) and bone marrow stromal cells (BMSCs) in repairing rabbits mandibular defects[J];Chinese Journal of Aesthetic Medicine;2005-05
7 Yang Weidong, Hu Ping, Qian Qichun, et al. Stomatological College, Fouth Military Medical University, Xi'an 710032 〔;Poly-beta-hydroxybutyrate as a scaffold for tissue-engineered cartilage[J];Journal of Practical Stomatology;2002-02
8 WANG Fang,FENG Chao,ZHOU Qinghai,et al.School of Basic Medical Sciences,Jilin University(Changchun 130021,China);Biological safey evaluation of modified PPC as a new biodegradable material[J];Chinese Journal of Public Health;2006-12
9 Zhao Zhen(School of History,Renmin University of China,Beijing,100872);The Layout of Weichang and Rise and Fall of Its Animals' Resources in the Qing Dynasty[J];Journal of Chinese Historical Geography;2009-01
10 Chen Jianquan,et al (Agricultural College,Yang Zhou University);Transgenic Mice Carrying xylE Mutational Target Gene[J];ACTA LABORATORIUM ANIMALIS SCIENTIA SINICA;1997-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved