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《Chinese Journal of Pharmacology and Toxicology》 2011-06
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Genetic toxicity of Bristletoothoak extract

LU Miao-gui1,JIANG Qiao-ling2,CAI De-lei3,ZHEN Yun-yan3 (1.Institute of Communicable Diseases Control,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;2.Department of Blood-Donation Service,Zhejiang Provincial Blood Center,Hangzhou 310006,China;3.Institute of Hygiene Toxicology,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China)  
OBJECTIVE To evaluate the genotoxicity of bristletoothoak extract.METHODSMicronucleus assay,karyotypes test,bacterial mutation assay(Ames test) and HGPRT forward mutation assay in V79 cell line,with presence or in absence of S9,were performed to determine the mutagenicity of bristletoothoak extract.Bristletoothoak extract 6.25,12.5,25,50 and 100 mg groups were set in Ames test,and number of reversional mutation colony was counted directly in culture medium.Bristletoothoak extract 2.5,5.0 and 10 g·L-1 groups were set in HGPRT forward mutation assay in V79 cell line,and colony was directly counted,and mutation frequency(MF) was calculated.Bristletoothoak extract 2.5,5.0 and 10.0 g·kg-1 groups were set,in micronucleus assay and karyotypes test and 1000 polychromatic erythrocytes(PCE),1000 complete sperms per animal were observed by microscopy,and PCE count with micronuclei count and type of malformed sperms were recorded,and micronuclei rate and sperm malformation rate was calculated.RESULTSBristletoothoak extract 100 mg per dish with or without S9,and the number of reversional mutation colony in Bristletoothoak extract groups was not higher than 2 times of that in solvent control group in Ames test,and MF in 3 Bristletoothoak extract groups was not satisfied with positive criteria,above 3 times of that in normal control group in mutation assay in V79 cell line.Ames test and gene mutation results in V79 cells showed negative.Compared with control group,micronuclei rate and sperm malformation rate had no significant difference among Bristletoothoak extract 2.5,5.0 and 10 g·kg-1 groups.CONCLUSION Bristletoothoak extract does not cause any measurable genotoxicity.
【CateGory Index】: R285.1
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