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《Chinese Journal of Pharmacology and Toxicology》 2011-06
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Progress in toxicology of realgar and its compound prescription

DONG Ju,WU Juan,WANG Ming-yan,ZHAN Zhen (Department of Preventive Medicine,Basic Medicine College,Nanjing University of Chinese Medicine,Nanjing 210046,China)  
Realgar is one of 28 kinds toxic Chinese herbal medicines issued by the Chinese Ministry of Health,and its major component is As4S4.Due to containing arsenic,the toxicity of realgar and its compounds has recently been a hot issue of concern,and the application in foreign countries has also been limited or even banned.Therefore,in order to understand the toxicity of realgar and its compounds comprehensively and correctly,a large number of toxicology studies,about their acute toxicity,chronic toxicity,special toxicity,as well as their relationship between the toxicity and the processing method,dosage,administration time of realgar and so on,have been carried out.In addition,some other issues,such as the toxicokinetics of realgar,the comparison of toxicity for realgar and its compounds and the chemical forms of arsenic(as arsenite) and so on,have also been studied.This paper reviewed the current toxicology studies of realgar and its compounds,and the existing questions and the directions of development would also be included.
【Fund】: 国家自然科学基金(30973715);; 江苏省高校研究生科研创新计划资助项目;; 江苏高校优势学科建设工程资助项目;; 江苏省高校自然科学基金项目(11KJD360001)~~
【CateGory Index】: R285
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