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《CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY》 1994-02
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Ultrastructure studies on antagonism of L一4一oxalysine to injury of hepatocytes caused by carbon tetrachloride in mice

DAIZhi一Qiang;YU Yue一Gui;YUAN Xing-Ju;Xu Jian-Yi;LIXiao -Yu(Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031)  
Hepatic cell injury by carbon tetrachloride(CCl4),ig.1%oil solvent of CCl410 mL·kg-1,in mice was assessed by electron microscopy.The toxic effects were markedly inhibited by L-4-oxalysine(I一677),50 mg· kg-1 ip being given twice daily for 2 d before CCl4.The fragmentation ofrough endoplasmic reticulum and the steatosis of hepatocytes were reduced obviously,The convalescence of injured hepatocytes was also faster than that of the control group without pretreatmentWith I一677.The ultrastructural observations indicated that I一677 induced the regional topolysis of cytoplasm of liver and loss of the cytoplasmic matrices.In the re-sult,the metabolism of CCl4 was inhibited,that maybe the main reason of I- 677 reducing the hepatic cellsinjury caused by CCl4 。
【CateGory Index】: R114
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