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《CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY》 1995-02
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Mimetic brain aging effect induced by D-galactose in mice

LI Wen-Bin;WEI Fen;FAN Ming;ZHANG Jin-Li;ZNANG Bing-Lie;MA Xian-Chen;YANG Wei-Ping;WEI Wen(Institute of Gerontology ane Geriatries, General Hospitalof People's Liberalion Army, Beijing,100853)  
The present results observed in mice treated with D-galactose(D-Gal,50 and 500 mg·kg-1·d-1 sc,6 wk)indicated that:1 D-Gal(50 mg·kg-1) diminished the number of correct response inswimming maze performance 2. The in RNA levelsof C-fos and H-ras as well as the intensity ofargyrophilic stain of nucleolus organizer region(AgNoR)of cortical and hippocampus neurons inD-Gal treated mice were decreased. 3.Thenucleus/plasma ratio, neuronal density, the contentsof total protein and RNA in neurons of cortex andhippocampus were decreased.In aged mice,the results also suggest s decreasedtranscription activity shown by above describedparameters except for C-fos mRNA level.N/P ratio and total RNA content in hippocampus neurons.It is concluded that the mimetic brain aging effecthas been induced by D-galactose injection.
【CateGory Index】: R339.38
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4 CAO Yan-ling1,2,LI Wen-lan1,WEI Ling-yu2,LIU Xiao-ya2,LI Zhi-hui2,HE Wei-guo3,ZHANG Yu-jie2*(1.Research Center for Life Science and Environmental Sciences,Haerbin University of Commerce,Haerbin 150028,China;2.School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine,Beijing 100102,China; 3.Beijing Medicass Biotechnologies Co.Ltd.,Beijing 100012,China);Anti-aging Function of Cycloastragenol in Aging Mice Induced by D-galactose[J];中国实验方剂学杂志;2012-19
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