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Mimetic brain aging effect induced by D-galactose in mice

LI Wen-Bin;WEI Fen;FAN Ming;ZHANG Jin-Li;ZNANG Bing-Lie;MA Xian-Chen;YANG Wei-Ping;WEI Wen(Institute of Gerontology ane Geriatries, General Hospitalof People's Liberalion Army, Beijing,100853)  
The present results observed in mice treated with D-galactose(D-Gal,50 and 500 mg·kg-1·d-1 sc,6 wk)indicated that:1 D-Gal(50 mg·kg-1) diminished the number of correct response inswimming maze performance 2. The in RNA levelsof C-fos and H-ras as well as the intensity ofargyrophilic stain of nucleolus organizer region(AgNoR)of cortical and hippocampus neurons inD-Gal treated mice were decreased. 3.Thenucleus/plasma ratio, neuronal density, the contentsof total protein and RNA in neurons of cortex andhippocampus were decreased.In aged mice,the results also suggest s decreasedtranscription activity shown by above describedparameters except for C-fos mRNA level.N/P ratio and total RNA content in hippocampus neurons.It is concluded that the mimetic brain aging effecthas been induced by D-galactose injection.
【CateGory Index】: R339.38
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