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《CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY》 1995-02
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Protective effcts of berberine on cerebral ischemia in mice and rats

WU Jun-Fang;SHI Yi-Ju; LIU Tian-Pei(Department of Pharmacology,Nanjing Medical University,Nanjing 210029;Department of Pharmacology,Tai'an Medical College,Tai'an 271000)  
erberine(Ber 5,10、20mg·kg-1,ip)significantly prolonged the survial time of micesubjected to cerebral ischemia by the occlusion of thebilateral carotid arteries. The mortality of the mice sub-jected to reperfuSion after cerebral ischemia was re-duced by Ber After acute incomplete cerebral ischemiain rats induced by hypotension coupled withhypoperfusion for 30 min, Ber (40 mg·kg -1 ip) mightmarkedly increase the activities of superoxidedismutase and decrease the concentration ofmalndialdehyde in plasma,as well as in hipocampusand cortex of the brain.in the model of local cerebralinfarction of rat produced by middle cerebral arteryocclusion,Ber(20, 40 mg·kg-1,ip before operation)decreased the infarct size and ameliorated neurologicdeficits,improved electroencephalogram changes in 2h occ1usion of rats.
【CateGory Index】: R277.733.1
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