Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY》 1999-02
Add to Favorite Get Latest Update

Protective effect of ecdysterone on amnesia induced by diazepam and alcohol 1

XU Nan Jie, GUO Yue Ying, RUI Wen Xia, LI Zhu, LI Xian (Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015)  
The protective effect of ecdysterone (ECR) on amnesia induced by diazepam and alcohol was studied by using the method of the one once trial of passive avoidance response including step down test and step through test, water maze test and shuttle box test. The results showed that ECR 1.8-14.4 mg·kg 1 prevented the diazepam (1.25 mg·kg 1 , ig) induced amnesia and the retrieval deficit induced by alcohol (2.5 g·kg 1 , ig) in mice in an inverted U dose response curve manner, ECR 3.6 and 7.2 mg·kg 1 antagonized the spatial discriminate damage induced by alcohol (0.5 g·kg 1 , ip) in mice, ECR 5.0 mg·kg 1 also protected rats against the impairment of multiple training active avoidance response induced by alcohol (2.0 g·kg 1 , ip). However, in the effective dose range influencing memory, ECR had no effect on the spontaneous locomotor activity, the pentobarbital sodium induced sleeping at the sub threshold dose of 30 mg·kg 1 and painthreshold in mice. These results indicate that ECR has protective effect against amnesia induced by diazepam and alcohol, and the influence of ECR on memory may be related to its antagonistic actions against the positive modulation of diazepam or alcohol on the GABAergic nervous system.
【Fund】: 国家自然科学基金
【CateGory Index】: R965.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 ZOU De-ping1,CAO Ling1,CHEN Qiu2(1 Department of Nephropathy,2 Department of Endocrinology,Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China);Advances in pharmacological research on ecdysteroids[J];中国新药杂志;2008-05
2 XU Shi-qing1,GE Zhi-qiang2,DAI Xuan-ying1,YI Hong-geng1,SIMA Yang-hu1,ZHENG Bi-ping1(1.College of Agriculture Science and Technology,Soochow University,Suzhou 215006,China;2.School of Life Since,Soochow University,Suzhou 215006,China);Research Progress on the Pharmacology and Medical Application of the 20-Hydroxyecdysone[J];科技通报;2005-01
China Proceedings of conference Full-text Database 1 Hits
1 XU Shi-qing~1 GE Zhi-qiang~2 SIMA Yang-hu~1 ZHENG Bi-ping~1 1.Department of applied biology and environmental science College of Agriculture Science and Technology & Institute of Sericulture,Soochow University,Suzhou 215006,China 2.School of Life Since,Soochow University,Suzhou 215006,China;STUDY ON THE PHARMACOLOGY AND MEDICAL APPLICATION OF THE 20-HYDROXYECDYSONE[A];[C];2004
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Xu Nanjie,Guo Yueying,Li Xian;Advances in Pharmacological Research on Ecdysterone[J];沈阳药科大学学报;1997-04
2 JC Pan and SS Zhang(Department of Pharmacology,Wenzhou Medical College,Wenzhou 325003);ANTAGONISM OF PIRACETAM ON THE AMNESTIC EFFECT OF DIAZEPAM IN MICE[J];药学学报;1996-02
3 Zhang Jun-tian and Saito H~*(Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing;) (~*Faculy of Pharmaceutical Sciences, University of Tokyo, Japan);STUDIES ON SUSCEPTIBILITIES TO THE AMNESTIC EFFECTS OF 12 CHEMICALS ON PASSIVE AVOIDANCE RESPONSES IN MICE: COMPARISON BETWEEN STEP DOWN AND STEP THROUGH TESTS[J];药学学报;1986-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Zhe;FENG Zhang-ying;ZHOU Wei;PANG Xiao-cong;LIAN Wen-wen;WU Song;LIU Ai-lin;DU Guan-hua;Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College;The Fourth Hospital of Hebei Medical University;;The effect of a novel isoflavonoid derivative J37941 on scopolamine-induced learning and memory deficits in mice[J];中国新药杂志;2017-10
2 Lu Zhenglin;Zhu Yong;Huang Ruisong;Li Yaohua;Guangxi Academy of Minority Nationality Medicine and Pharmacology;Guangxi University of Chinese Medicine;;Research on quality standards of minority areas specialty herbs medicine Vitex quinata[J];广西医科大学学报;2017-04
3 ZHANG Ying;YANG Liu;ZHANG Yan-yan;JIANG Hai;YANG Bing-you;WANG Qiu-hong;XIAO Hong-bin;KUANG Hai-xue;Key Laboratory of Chinese Materia Medica (Ministry of Education) ,Heilongjiang Key Laboratory of TCM Pharmacidynamic Material Bases,Heilongjiang University of Chinese Medicine;;Determination of Contents of Split Fractions of Radix Achyranthis Bidentatae[J];中医药信息;2015-05
4 WANG Huan;ZHOU Ming;LI Zeyang;SHEN Shuting;School of Animal Science and Technology, Anhui Agricultural University;;Functional feed additives and their effects on the growth and serum biochemical parameters of calves[J];安徽农业大学学报;2015-02
5 Han Chunni;He Fangyan;Tian Ye;Duan Xiaohua;Yunnan University of Traditional Chinese Medicine;;Effects of Extractive from Gastrodiae Rhizoma on Cholinergic System in Mouse Memory Acquisition Barrier Model[J];中国药业;2014-21
6 LIU Fang;ZHANG Li-min;XIAO Guan-li;LI Zheng-yue;CHEN Bin;DU Yan-jiao;College of Plant Protection,Yunnan Agricultural University;College of Basic Science and Information Engineering,Yunnan Agricultural University;College of Agronomy and Biotechnology,Yunnan Agricultural University;;Study on the Dynamics of Physiology and Biochemistry During the Process of Germination of Cyanotis arachnoidea[J];种子;2014-09
7 HAN Chun-ni;HE Fang-yan;TIAN Ye;DUAN Xiao-hua;Yunnan University of Traditional Chinese Medicine;;Effects of Extractive from Gastrodiae Rhizoma on Learning-Memory Function in Mice[J];中国中医药信息杂志;2014-09
8 Qiu xin;Wu Leibin;Chen Guohua;Department of Neurology,Wuhan Combining Chinese and Western Medicine Hospital;;Effects of Xiaoyaosan on behavior and free radical metabolism in Alzheimer's disease model mice with chronic mild stress[J];卒中与神经疾病;2014-04
9 LV Shan-shan;TANG Gui-ying;YANG Chao;ZHOU Nian-hua;CHEN Cheng;CHEN Xiao-xue;CHEN Li;QIAO Zhi-wen;Chongqing Healn Pharmaceutical Co.,Ltd;;The Improving Effect of Pediatric Huanglong Granule on Mouse Models with Memory Dysfunction[J];中国实验方剂学杂志;2014-14
10 ZHANG Pei-hai;PAN Jun-jie;LI Guang-sen;Chengdu University of Traditional Chinese Medicine;Department of Andrology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine;Meishan Hospital of TCM;;Clinical Research of Treating Kidney Deficiency and Blood Stasis Type of Benign Prostatic Hyperplasia with Shuang-Hu Capsule[J];成都中医药大学学报;2014-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WU Xu ①,ZHAO Zhong ②,ZHANG Jun Hua,ZHENG Yong ② ( ①Research Institute of Field Surgery,Affiliated Daping Hospital,Third Military Medical University,Chongqing 400042) ( ②Department of Cardiothoracic Surgery,309th Hospital of PLA,Beijing 1000;Effect of Ecdysterone on arrhythmia induced by myocardium reperfusion[J];解放军药学学报;2002-01
2 WU Ji biao,SUI Zai yun,ZHANE Ling ( Institute of TCM of Shandong Province ,Jinan 250014,China);EXPERIMENTAL STUDIED ON THE ANTI-AGING EFFECT OF β-ECDYSTERONE[J];天然产物研究与开发;2001-05
3 JIN Jun, HUANG Lan,ZHU Shan Jun,XIANG Chang Qing,LI Hong (Dept of Cardiology,Xingqiao Hospital, the Third Military Medical University,Chongqing 40037);Effect of ecdysterone on apoptosis induced by hypoxia in HUVECs[J];中国药理学通报;2001-05
4 WU Xu ①,SHI Fu Sheng ②,LIANG Zi Wen ③ ( ① Research Institute of Field Surgery,Affiliated Daping Hospital,Third Military Medical University,Chongqing 400042) ( ② Department of Burn,322nd Hospital,PLA,Datong 037006,Shanxi) ( ③ Department;Experimental Study of Ecdysterone on Revascularization in Rat Ischemic Myocardium[J];解放军药学学报;2001-05
5 WU Xu 1, JIN Jun 2, LIANG Zi wen 3, SHI Fu sheng 4 (1 Institute of Field Surgery, Affiliated DAPING Hospital, Third Military Medical University, Chongqing 400042, China; 2 Department of Cardiology, Affiliated XINQIAO Hospital, Third Militar;Beneficial effect of ecdysterone on rat myocardial infarction induced by coronary occlusion[J];中草药;2001-08
6 SHI Fu sheng, YANG Ri gao, DI Gui ping, LUO Xiang dong, YANG Zhong cheng, WU Xu (Department of Burn Injury, No.322 Hospital of PLA, Datong 037006, China);Protective effect of ecdysterone on TNF-induced HUVEC in vitro[J];第三军医大学学报;2000-08
7 JIN Jun, HUANG Lan, XIANG Chang Qing, LI Hong, WU Xu, GENG Jian Meng (Dept of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037);Effects of ecdysterone on collateral formation and expression of VEGF in rat AMI[J];中国药理学通报;2000-04
8 XuNanjie,GuoYueying ,RuiWenxia ,LiZu ,LiXian DepartmentofTraditionalChineseMedicines ,ShenyangPharmaceuticalUniversity ,Shenyang 110 0 15;The Improving Effect of Ecdysterone on Scopolamine-lnduced Amnesia[J];沈阳药科大学学报;1999-04
9 XU Nan Jie, GUO Yue Ying, LI Xian (Dept of Physiology, Shenyang Pharmaceutical University, Shenyang 110015);Protective effect of ecdysterone on cerebral hypoxia in mice[J];中国药理学通报;1999-03
10 XU Nan Jie, GUO Yue Ying, RUI Wen Xia, LI Zhu, LI Xian (Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015);Protective effect of ecdysterone on amnesia induced by diazepam and alcohol 1[J];中国药理学与毒理学杂志;1999-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 PAN Zi-Feng;LI Nan;LIU Shuang;CHEN Rong-Yi;Department of Dermatology,Affiliated Hospital of Guangdong Medical University;;Feasibility of treating the scar with shrimp blood active ingredients[J];医学争鸣;2017-03
2 LIU Shuang;LAI Yin-xuan;LI Nan;WU Zhi-xian;WAN Dan-chun;PAN Zi-feng;CHEN Rong-yi;Department of Dermatology, The Affiliated Hospital of Guangdong Medical University;Health management and medical examination center, The Affiliated Hospital of Guangdong Medical University;Department of Plastic surgery , The Affiliated Hospital of Guangdong Medical University;First Clinical School, Guangdong Medical University;;The effects of 20-Hydroxyecdysone on the proliferation and Smad3 mRNA expression of hypertrophic scar fibroblasts in vitro[J];广东医学院学报;2016-06
3 XIA Xi-chao;TANG Nian-ya;XUE Shi-peng;WANG Xi-ying;WANG Wei-na;LIU Rongzhi;Basal Medicine College of Nanyang Medical University;;Effects of 20- hydroxyecdysone on expression of inflammation cytokines in acute lung injury mice[J];现代预防医学;2016-05
4 ZHANG Qing-yuan;XIA Xi-chao;WANG Zhong-xiao;JIANG Xiao;LIANG Gui-na;Basic medical department,Nanyang medical university;;Effect of 20-hydroxyecdysone on glucokinase and tumor necrosis factor- αin type I diabetes mellitus of mice[J];现代预防医学;2015-16
5 JIANG Xiao;XIA Xi-chao;WANG Hai-xin;TANG Nian-ya;ZHANG Qing-yuan;WU Hong-fang;SUN Xiu-li;WANG Li-juan;LIU Rong-zhi;Basic medical department, Nanyang Medical College;;20-hydroxyecdysone anti-oxidative ability on hippocampus of rat with type 2 diabetes[J];现代预防医学;2015-13
6 ZHANG Qing-yuan;XIA Xi-chao;WANG Zhong-xiao;JIANG Xiao;LIANG Gui-na;Department of Basic Medicine,Nanyang Medical College;;Glucose-lowering effect of 20-hydroxyecdysone on type 1 diabetes mellitus of mice[J];中国实用医刊;2015-13
7 ZHANG Huan;YANG Zhong-lin;ZHENG Zhuo;XIAO Wei;WANG Zheng-zhong;DING Gang;HUANG Wen-zhe;State Key Laboratory of Natural Products and Functions,China Pharmaceutical University;Jiangsu Kanion Pharmaceutical Corporation;;Effect of β-Ecdysone on Oleic Acid-induced Fat Accumulation in HepG2 Cells[J];海峡药学;2015-04
8 PENG Fei;LU Yang;MA Jifu;XI Weijia;MA Ji;College of Life Science,Shaanxi Normal University;Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry,Ministry of Education;;Research Progress in Breeding and Application of Matteuccia struthiopteris[J];贵州农业科学;2014-12
9 XIA Xi-chao;GUI Gai-xia;LIU Chang-hai;LI He-wen;LIU Jin-hui;Department of Fundamental Medicine,Nanyang Medical College;;The effect of 20-hydroxyecdysone on carbon tetrachloride-induced liver injuries in mice[J];现代预防医学;2013-24
10 WANG Dan-chun;CHEN Rong-yi;LI Ming-yong;ZHU Xiao-min;LIANG Zhi-peng;CHEN Mao-zhong;HUANG He-meng;First Clinical School, Guangdong Medical College;Department of Dermatology, The First Affiliated Hospital of Guangdong Medical College;Physical Science Teaching and Research Section,Guangdong Medical College;;Effects of Shrimp Blood on the Hypertrophic Scar in Rabbit Ears[J];广东海洋大学学报;2013-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved