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Protective effect of ecdysterone on amnesia induced by diazepam and alcohol 1

XU Nan Jie, GUO Yue Ying, RUI Wen Xia, LI Zhu, LI Xian (Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015)  
The protective effect of ecdysterone (ECR) on amnesia induced by diazepam and alcohol was studied by using the method of the one once trial of passive avoidance response including step down test and step through test, water maze test and shuttle box test. The results showed that ECR 1.8-14.4 mg·kg 1 prevented the diazepam (1.25 mg·kg 1 , ig) induced amnesia and the retrieval deficit induced by alcohol (2.5 g·kg 1 , ig) in mice in an inverted U dose response curve manner, ECR 3.6 and 7.2 mg·kg 1 antagonized the spatial discriminate damage induced by alcohol (0.5 g·kg 1 , ip) in mice, ECR 5.0 mg·kg 1 also protected rats against the impairment of multiple training active avoidance response induced by alcohol (2.0 g·kg 1 , ip). However, in the effective dose range influencing memory, ECR had no effect on the spontaneous locomotor activity, the pentobarbital sodium induced sleeping at the sub threshold dose of 30 mg·kg 1 and painthreshold in mice. These results indicate that ECR has protective effect against amnesia induced by diazepam and alcohol, and the influence of ECR on memory may be related to its antagonistic actions against the positive modulation of diazepam or alcohol on the GABAergic nervous system.
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