Therapeutic effect of hydroxychloroquine combined with clarithromycin and medical moisturizer on rosacea
LIN Da-shan;JIANG Lian-zhi;WANG Ya-li;Quanzhou Skin Disease Prevention and Treatment Hospital;
Objective To study and analyze the efficacy of hydroxychloroquine combined with clarithromycin and medical moisturizer in the treatment of rosacea. Methods From January 2017 to January 2018, we collected 48 cases of patients diagnosed with rosacea in the outpatient department of our hospital, which were divided into observation group and control group. Control group was given 0.5 qd clarithromycin sustained-release tablets combined with external medical moisturizer; Oral hydroxychloroquine 0.1 bid was added to the control group. Both groups used 4 W continuously. After the treatment of 2 W and 4 W, the differences in objective signs, conscious symptoms and adverse drug reactions between the two groups were compared, and statistical methods were used to calculate whether the differences between the two groups were statistically significant(P 0.05). Results The total effective rate of the control group after 2 W and 4 W was 45.83% and 58.33%, respectively, significantly lower than that of the observation group(72.92% and 85.41%), and the difference was statistically significant(P 0.05). The total score of the disease was significantly lower than that before treatment, and the difference was statistically significant(P 0.05). No significant side effects were found during treatment and follow-up. Conclusion The efficacy of hydroxychloroquine combined with clarithromycin and medical moisturizer in the treatment of rosacea is better than that of oral clarithromycin combined with medical moisturizer.
【CateGory Index】： R758.734