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《Chinese Journal of Clinical Pharmacology and Therapeutics》 1997-01
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Efficacy of tablet huperzine - A on memory and cognition in patients with benign senescent forgetfulness

Xu Sisun Xie Haibao2 Du Zunming Tong Zhenhua Shi Qichang Lu Keming1 Li Shulan2 Lin Bing1 (Zhejiang Supervising and Detecting Drug Station of ZheJiang Medical College, Hangzhou 310009; 1Zhejiang Hospital, Hangzhou 310005; 2Hangzhou Central Hospital of Rail  
Aim To evaluate the efficacy and safety of tablet huperzine - A(Hup) in patients with benign senescent forgetfulness. Methods Using multicenter, prospective, double - blind, parallel, placebo controlled and randomized method, 50 patients were administrated orally 0.15mg (3 tablets ) Hup and 50 patients were given po 3 tablets of placebo bid for 4 wk. All patients were evaluated with Wechsler memory scale, mini - mental state examination scale, treatment emergency symptom scale, and measured BP, HR, ECG, EEG, ALT, AKP, BUN, Cr, Hb, WBC, and urine routine. Results Seventy four percent of patients treated with Hup (37/50) showed improvements in their memory (P0.01 ) and cognitive functions(P0.01). The efficacy of Hup was better than placebo(40%, 20/50) (P 0. 05). No severe cholinergic side effect was found. Conclusion Hup is an ideal drug for symp- tomatic treatment of patients with benign senescent forgetfulness.
【CateGory Index】: R969
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【References】
Chinese Journal Full-text Database 1 Hits
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIAO Jianxiang, CHEN Li, HUANG Tieshuan, LI Bing(Department of Pediatric Neurology, Shenzhen Children's Hospital 518026);Pilot trial of huperzine A to treat child language delay[J];Journal of Pediatric Pharmacy;2002-01
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【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 JIANG Yu-Ren XU Hui CHEN Fang-Jun MA Guan-Jun (College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China);Molecular Docking of the Acetylcholinesterase Inhibitor Corydaline and Virtual Screening of Open Ring Derivatives[J];Acta Physico-Chimica Sinica;2009-07
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