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《Chinese Journal of Clinical Pharmacology and Therapeutics》 2006-06
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Effect of chlorotoluron system on the testis of mice

MU Hong,ZHANG Ping~1,YANG Sheng-ying~2,XU Jian~2 Medical College of Nankai University,Tianjin 300071,China;~1 College of Environmental Science and Engineering,Nankai University,Tianjin 300071,China;~2 Chemistry College,Nankai University,Tianjin 300071,China  
AIM:To study the effect of chlorotoluron system on the tesis of mice.METHODS:Male mice were contaminated with chlorotoluron by oral for 25 days.RESULTS: It indicated that all doses of herbicide had different changes.It was detected that under the light microscope seminaferous epithelium arrayed loosely and disorderedly,spermatogenic cell shed,layers lessened,while under the electron microscope mitochondria in the seminaferous epithelium appeared vacuolated,karyotheca swelled and bent,the amount of sustentacular cell declined,and part of tight junction destroyed.CONCLUSION: The trend of degeneration and more seriously pathological changes appeared with increasing doses.
【CateGory Index】: R114
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